5-Fu腹腔冲洗联合局部植入用于结直肠癌腹腔镜根治术中的价值分析  

Effect of 5-Fu abdominal irrigation combined with local implantation in laparoscopic colorectal surgery

作　　者：陆王锋 田晓建 王希方 Lu Wangfeng;Tian Xiaojian;Wang Xifang(Department of Gastrointestinal Surgery,Shangluo Central Hospital,Shangluo 726000,Shaanxi,China;Department of Oncology,Shaanxi Provincial People’s Hospital,Xi’an 710068,Shaanxi,China)

机构地区：[1]商洛市中心医院胃肠外科,陕西商洛726000 [2]陕西省人民医院肿瘤内科,陕西西安710068

出　　处：《结直肠肛门外科》2019年第3期289-293,共5页Journal of Colorectal & Anal Surgery

基　　金：陕西省科学技术研究发展计划项目(编号:2017K12-04053)

摘　　要：目的研究5-氟尿嘧啶(5-Fu)腹腔冲洗联合局部植入用于结直肠癌腹腔镜根治术中的临床价值。方法纳入2013年7月至2015年7月陕西省人民医院收治的80例结直肠癌患者作为研究对象,根据入院顺序奇偶将患者分为观察组和对照组,每组各40例。两组均接受腹腔镜结直肠癌根治术,两组在关腹前用5-Fu冲洗盆腹腔,观察组在此基础上将5-Fu局部植入切除病灶的区域。比较两组手术时间、术中出血量、术后肛门排气时间及术后住院时间,记录术后不良反应和并发症发生情况,随访比较两组术后3年生存情况。结果两组术中出血量、术后肛门排气时间及术后住院时间比较,差异均无统计学意义(均P>0.05),观察组手术时间较对照组延长,差异有统计学意义(P<0.05)。两组骨髓抑制、胃肠道反应、口腔黏膜炎及肝肾功能异常发生率比较,差异均无统计学意义(均P>0.05)。两组并发症总发生率比较,差异无统计学意义(P>0.05)。两组总生存率比较,差异无统计学意义(P>0.05)。两组无进展生存率比较,差异有统计学意义(P<0.05)。结论5-Fu腹腔冲洗联合局部植入用于结直肠癌腹腔镜根治术中,有助于延长患者术后无进展生存时间,且未见增加毒副反应发生率。Objective To investigate the value of 5-Fu abdominal irrigation combined with local implantation in laparoscopic colorectal surgery. Methods Eighty patients with colorectal cancer treated in Shaanxi Provincial People’s Hospital from July 2013 to July 2015 were divided.into treatment group (n = 40) and control group (n = 40), according to their admission order (al. ternating allocation according to odd or even sequence). All patients received laparoscopic radical surgery for colorectal cancer. Before closing, patients in the treatment group received 5-Fu abdomial irrigation and 5-Fu was locally implanted in the resected area, while patients in the treatment group received 5-Fu abdomial irrigation only. The operation time, intraoperative blood loss, postoperative anal exhaust time and postoperative hospital stay were compared between the two groups, the side effects and com. plications were recorded, and both groups were followed up for 3 years. Results There were no significant difference in intraop. erative blood loss, postoperative anal exhaust time and postoperative stay between the two group (P > 0.05). The operation time was significantly longer in the control group (P < 0.05). There was no significant difference in incidence of myelosuppression, gastrointestinal reaction, oral mucositis, and abnormal liver and kidney function between the two groups (P > 0.05). Total inci. dence of complications and overall survival were comparable between the two groups (P > 0.05). There was significant difference in progression-free survival between the two groups (P < 0.05). Conclusion 5-Fu abdominal irrigation combined with local im. plantation in laparoscopic colorectal surgery could improve patients’progression-free survival, whilst the incidence of toxicity is not increased.

关 键 词：结直肠癌 5-FU 腹腔冲洗 局部植入 

分 类 号：R735.3[医药卫生—肿瘤]