人二倍体细胞狂犬病疫苗不良反应发生率Meta分析  

A Meta-analysis on adverse drug reactions rate of human diploid ceil rabies vaccine

作　　者：李帆[1] 吕强[1] 祝小平[1] 王戈[2] 周兴余[1] Li Fan;LV Qiang;ZHU Xiaoping;WANG Ge;ZHOU Xingyu(Sichuan Center for Disease Control and Prevention,Chengdu 610041. China)

机构地区：[1]四川省疾病预防控制中心,成都610041 [2]德阳市绵竹市疾病预防控制中心

出　　处：《中国急救复苏与灾害医学杂志》2019年第6期548-552,共5页China Journal of Emergency Resuscitation and Disaster Medicine

摘　　要：目的对狂犬病暴露后全程接种人二借体细胞狂犬病疫苗(human diploid cell rabies vaccine,HDCV)人群的不良反应发生率进行Meta分析,为狂犬病疫苗接种策略提供理论依据:方法通过检索中国知网、中国生物医学文献服务系统、维普期刊资源平台、万方数据知识服务平台、PubMed数据库,Google学术数据库.SeienceDireil数据库和Cochrane Library数据库中已发表的与HDCV接种不良反应相关的研究文献,检索时限为1970年01月-2018年07月;根据纳入与排除标准进行数据整理.并利用R软件对不良反应发生率进行Meta数据分析结果合计纳入19篇中英文文献,且所纳入的文献无明显的发表偏倚"纳入文献中接种HDCV的总调查人数为7239人,全身不良反应的合并发生率为16.63%,局部不良反应的合并发生率为34.07%;国外HDCV接种后全身不良反应发生率为20.76%,局部不良反应发生率为42.97%;国产HDCV接种后全身不良反应发生率为2.47%,局部不良反应发生率为4.22%;两组数据差异有统计学意义(P<0.01)。国外HDCV接种不良反应合并发生率为13.44%~29.19%,国产HL)CV接种不良反应合并发生率为0.23%~6.98%,两组数据差异有统计学意义(P<0.01)结论国产HDCV不良反应发生率低,具有良好的安全性。Objective We conducted a Meta-analysis on the incidence of adverse drug reactions among people who received a full immunization with liuman diploid cell rabies vaccine (HDCV) throughout the world, in order to provide theorrtieal basis for the development of rabies vaccination regimen. Method Nineteen literatures about studies on the incidence of adverse drug reactions vaccinated with HDCV, from January, 1970 lo July, 2018, were collected from the dalabasrs including China Knowledge Resource Integrated Database (CM KI), SinoMed. Pub Med. VIP Journal Integration Pkitforni. anfang Data,(ioogle Scholar, ScienceDirect and Cochrane Library. I he collected data were strictly organized according lo the inclusion and exclusion criteria, and Meta-analysis on the incidence of adverse drug reactions vviis conducted by R software. Result A total of 19 English and Chinese studies were included in ihe analysis, without any obvious bias. 7239 cases vaccinated vvilli HDCV in total had been investigated. The local adverse drug reactions rate was 34.07%. while the systemic adverse drug reactions rale was 16.63%. The systemic and local adverse drug reactions rate of foreign HDCV was 20.76% and 42.97% respectively, meanwhile the systemic and local adverse dnig reactions rate of Cliinrse HDCV was only 2.47% and 4.22% respectively. There is a significant difference between these two vaccinr catrgories (P<0.0l). The combined incidence rate of foreign rabies vaccines was 13.44%-29.19%, and that of the Chinese rabies vaccine was 0.23%-6.98%. which shows significiiiit difference between the two groups (P<0.01). Conclusion I he adverse drug reactions rate caused by Chinese HDCV was significtmlly lower than thcit of foreign rabies vaccines, demonstrating Chinese HDCA has salisfactoiy safety and tolerance.

关 键 词：狂犬病 人二倍体细胞北:犬病疫苗 不良反应 META分析 

分 类 号：R392[医药卫生—免疫学]