二甲双胍在非糖尿病疾病治疗中的应用进展  

Application of metformin in the treatment of non-diabetic diseases

作　　者：杨雄[1] 安能 杨瑞[1] 李杰[1] 史启铎[1] 刘春雨[1] Yang Xiong;An Neng;Yang Rui;Li Jie;Shi Qiduo;Liu Chunyu(Urolithiasis Treatment Center,The Second Hospital of Tianjin Medical University,Tianjin Institute of Urology,Tianjin 300211,China)

机构地区：[1]天津医科大学第二医院尿石症治疗中心,天津市泌尿外科研究所,300211

出　　处：《国际生物医学工程杂志》2019年第2期166-170,共5页International Journal of Biomedical Engineering

基　　金：国家自然科学基金青年项目(81700616);天津市科技计划项目(18PTLCSY00020).

摘　　要：目前二甲双胍是治疗2型糖尿病(T2DM)的一线药物,是世界上应用最为广泛的口服降糖药物。二甲双胍除具有显著的降糖作用外,还对肿瘤、肥胖、甲状腺、多囊卵巢和心血管等疾病具有潜在的治疗作用。然而,其具体的药物作用机制尚不清楚。大量研究数据表明,二甲双胍对能量代谢的调节作用不仅是治疗T2DM药物作用机制的核心,也是其在肿瘤和心血管等疾病中发挥治疗作用的重要机制。对二甲双胍在非糖尿病疾病治疗中的诸多临床应用和相关药物机制进行综述,以期为广大医务工作者提供参考,并期待今后对其药物作用机制及临床应用进行更加深入的探索和拓展。Metformin is currently the first-line drug for the treatment of type 2 diabetes,and it is the most widely used oral hypoglycemic drug in the world. In addition to its significant hypoglycemic effect,metformin also has potential therapeutic effects on diseases such as tumors,obesity,thyroid diseases,polycystic ovarian diseases and cardiovascular diseases. However,the specific mechanism of action of metformin is still unclear. A large number of studies have shown that the regulation of energy metabolism by metformin is not only the core of its mechanism of action in the treatment of type 2 diabetes,but also an important mechanism for its therapeutic effects in diseases such as tumors and cardiovascular diseases. In this paper,the clinical application and related drug mechanisms of metformin in the treatment of non-diabetic diseases were summarized,so as to provide reference for the majority of medical workers,and look forward to a more in-depth exploration of its drug mechanism and clinical application in the future.

关 键 词：二甲双胍 肿瘤治疗 机制 腺苷酸激活蛋白激酶 

分 类 号：R977.15[医药卫生—药品]