妊娠早期血清25羟基维生素D水平与妊娠期高血压及疾病严重程度的相关分析  

Correlation of serum 25-hydroxy-vitamin D level at early pregnancy with gestational hypertension and its severity

作　　者：韩懿[1] 司徒文慈[1] 雷巧茹[2] HAN Yi;SITU Wen-ci;LEI Qiao-ru(Department of Obstetrics,Central Hospital,Kaiping City,Guangdong Province,Kaiping 529300,Guangdong Province;Guangdong Kaiping Central Hospital Gynecology,Guangdong Kaiping 529300)

机构地区：[1]广东省开平市中心医院产科,广东开平529300 [2]广东省开平市中心医院妇科,广东开平529300

出　　处：《广东医科大学学报》2019年第3期256-260,共5页Journal of Guangdong Medical University

基　　金：江门市科技计划项目(No.江科[2014]79号)

摘　　要：目的探讨妊娠早期血清25羟基维生素D[25(OH)D]水平与妊娠期高血压及疾病严重程度的相关性。方法选取376例妊娠早期孕妇作为研究对象,根据第12~18孕周的血清25(OH)D水平分为25(OH)D充足组(181例)、不足组(90例)、轻度缺乏组(58例)和严重缺乏组(47例),比较各组妊娠期高血压的发生率。采集孕妇的社会人口学特征、疾病史、实验室检查、临床资料等信息,分析妊娠期高血压发生的影响因素。结果 376例孕妇中共有88例发生妊娠期高血压,发生率为23.40%(88/376)。随着血清25(OH)D水平的降低,妊娠期高血压发生率逐渐升高(P<0.05或0.01)。正常妊娠组、妊娠期高血压组、轻度子痫前期组和重度子痫前期组孕妇的年龄、孕前BMI、孕早期血清25(OH)D水平、妊娠期高血压家族史和孕期负性情绪的比较差异有统计学意义(P<0.05或0.01)。多因素Logistic回归分析显示,年龄、孕早期血清25(OH)D水平、孕前BMI、妊娠期高血压家族史和孕期负性情绪是妊娠期高血压发生的独立影响因素(P<0.05或0.01)。结论孕早期高水平血清25(OH)D是妊娠期高血压疾病的独立危险因素,与疾病严重程度密切相关。Objective To investigate the correlation of serum 25-hydroxy-vitamin D level [25(OH)D] at early pregnancy with gestational hypertension and its severity. Methods A total of 376 patients at early pregnancy were selected as research objects and divided into four groups according to the serum 25(OH)D level at the 12th to 18th gestational week, namely, Sufficiency Group (n=181), Insufficiency Group (n=90), Mild Deficiency Group (n=58), and Serous Deficiency Group (n=47). The incidence of gestational hypertension of these four groups was compared. Moreover, the information of sociodemographic characteristics, disease history, laboratory examinations and clinical data of the pregnant women were also collected and analyzed to explore the risk factors of the incidence of gestational hypertension. Results Of the 376 pregnant women, 88 cases had gestational hypertension, and the incidence was 23.40%(88/376). The incidence of gestational hypertension was gradually increased with the decrease of serum 25(OH)D level. There were statistical differences in the age, pre-pregnant BMI, serum 25(OH)D, family history of gestational hypertension, and negative emotion during pregnancy among the Normal Gestation Group, Gestational Hypertension Group, Mild Preeclampsia Group and Severe Preeclampsia Group (P<0.05 or 0.01). Multivariate logistic regression analysis indicated that age, serum 25(OH)D, pre-pregnant BMI, family history of gestational hypertension and negative emotion during pregnancy were the independent risk factors of gestational hypertension (P<0.05 or 0.01). Conclusion High serum 25(OH)D level at early pregnancy is an independent risk factor of gestational hypertension and is closely related to its severity.

关 键 词：25羟基维生素D 妊娠期高血压 严重程度 影响因素 

分 类 号：R714.2[医药卫生—妇产科学]