金水宝胶囊联合吗替麦考酚酯治疗狼疮性肾炎的疗效观察  

Therapeutic efficacy of combined Jinshuibao capsule and mycophenolate mofetil in lupus nephritis

作　　者：刘国钦[1] 胡国强[2] 冼玉荣 曾贵林[1] LIU Guo-qin;HU Guo-qiang;YAN Yu-rong;ZENG Gui-lin(Department of Nephrology and Endocrinology,Xinhui People’s Hospital;Department of Nephrology,Jiangmen Central Hospital,Jiangmen 529100,China)

机构地区：[1]广东省江门市新会区人民医院肾内内分泌科 [2]广东省江门市中心医院肾内科,广东江门295100

出　　处：《广东医科大学学报》2019年第3期345-348,共4页Journal of Guangdong Medical University

摘　　要：目的察金观水宝胶囊与吗替麦考酚酯(MMF)联合治疗狼疮性肾炎的效果。方法58例狼疮性肾炎患者在甲泼尼龙冲击治疗后,分别采用泼尼松及MMF(对照组)或泼尼松、MMF及金水宝胶囊(实验组)治疗6个月。比较两组疗效、不良反应及血清抗dsDNA抗体、补体C3水平。结果实验组疗效、抗dsDNA抗体转阴率、补体C3正常率明显高于对照组(P<0.01或0.05),而不良反应低于对照组(P<0.05)。结论水宝金胶囊联合MMF治疗狼疮性肾炎可提高疗效,减少不良反应。Objective To observe the efficacy of combined Jinshuibao capsule and mycophenolate mofetil (MMF) in lupus nephritis. Methods After methylprednisolone pulse therapy, 58 patients with lupus nephritis were treated with oral prednisone and MMF (control group) or prednisone, MMF and Jinshuibao capsule (experimental group) for 6 months. Clinical efficacy, adverse reactions, and serum levels of anti-dsDNA antibody and complement C3 were compared between 2 groups. Results Compared with control group, clinical efficacy, negative conversion rate of anti-dsDNA antibody and normalization rate of complement C3 were higher (P<0.01 or 0.05) but adverse reactions were lower (P<0.05) in experimental group. Conclusion Combined Jinshuibao capsule and MMF can improve clinical efficacy and reduce adverse reactions in patients with lupus nephritis.

关 键 词：金水宝胶囊 吗替麦考酚酯 狼疮性肾炎 

分 类 号：R593.24[医药卫生—内科学]