α-重氮-1,3-二羰基化合物的合成  

Synthesis ofα-diazo-1,3-dicarbonyl compounds

作　　者：张资序 王艳芳[2] 李云辉[1] ZHANG Zi-xu;WANG Yan-fang;LI Yun-hui(School of Chemistry and Evironmental Engineering,Changchun University of Science and Technology,Changchun 130022,China;Baicheng City Taobei District of Animal Quarantine Station,Baicheng 130000,China)

机构地区：[1]长春理工大学化学与环境工程学院,吉林长春130022 [2]白城市洮北区动物检疫站,吉林白城130000

出　　处：《东北师大学报（自然科学版）》2019年第2期101-107,共7页Journal of Northeast Normal University(Natural Science Edition)

基　　金：吉林省科技发展计划项目(20170204038GX)

摘　　要：通过重氮基团的转移方法合成了3种不同类型的α-重氮-1,3-二羰基化合物(α-重氮苯甲酰丙酮、α-重氮乙酰乙酸乙酯和α-重氮乙酰乙酰苯胺),并研究了1,3-二羰基化合物的种类、溶剂、重氮转移试剂及碱的强弱对这3种类型的α-重氮-1,3-二羰基化合物产率的影响.得到α-重氮苯甲酰丙酮、α-重氮乙酰乙酸乙酯和α-重氮乙酰乙酰苯胺的最优产率分别为92%、90%和85%,该合成方法具有操作简便、收率高和原材料便宜易得等优点.Three different types ofα-diazo-1,3-dicarbonyl compounds(α-diazo benzoylacetone,α-diazoacetoacetate andα-diazoacetoacetanilide)were synthesized by the method of diazonium group transfer.The effects of the type of 1,3-dicarbonyl compound,solvent,diazo transfer reagent and the strength of alkali on the yield of these three types ofα-diazo-1,3-dicarbonyl compounds were systematically studied.The optimum yields ofα-diazo benzoylacetone,α-diazoacetoacetate andα-dicarboxylate were 92%,90% and 85%,respectively.The synthesis method has many advantages,such as ease of operation,high yield and easy availability of raw materials.

关 键 词：α-重氮苯甲酰丙酮 α-重氮乙酰乙酸乙酯 α-重氮乙酰乙酰苯胺 重氮转移 

分 类 号：O621[理学—有机化学]