膀胱癌图像引导放疗中基于骨骼与基于内植标记物锥形束CT校准比较  

Comparison between CBCT calibrations based on skeleton vs implanted markers in image-guided radiotherapy for bladder cancer

作　　者：田龙[1] 席强[1] 赵鑫[1] 刘月霞[2] 张遵浩 TIAN Long;XI Qiang;ZHAO Xin;LIU Yuexia;ZHANG Zunhao(The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, China;School of Clinical Medicine, Zhangjiakou Education College, Zhangjiakou 075000, China;The First Hospital of Hebei Medical University, Shijiazhuang 050000, China)

机构地区：[1]河北北方学院附属第一医院,河北张家口075000 [2]张家口教育学院临床医学院,河北张家口075000 [3]河北医科大学第一医院,河北石家庄050000

出　　处：《中国医学物理学杂志》2019年第6期647-652,共6页Chinese Journal of Medical Physics

基　　金：河北省卫健委项目(20190892)

摘　　要：目的:以基于内植标记物校准为参考,比较其与基于骨骼校准之间准确性的差异。方法:筛选12名膀胱癌患者并植入标记物,所有病人治疗前接受MV级锥形束CT扫描,并执行基于内植标记物和骨骼两种校准。最后回顾性分析两种校准在左右(LR)、上下(SI)和前后(AP)及3D空间向量上的差异平均值。结果:两种校准在左右(LR)、上下(SI)和前后(AP)及3D空间向量上差异平均值分别为3.2、6.1、2.6和8.6 mm。结论:膀胱癌图像引导放疗中基于相邻骨骼自动校准在准确度上劣于基于膀胱内植标记物的手动校准,避免标记物植入和新的图像计算、分析方法是未来的发展趋势。Objective With the calibration based on implanted markers as a reference, to compare the differences in accuracy between calibrations based on skeleton vs implanted marker. Methods Twelve bladder cancer patients who were implanted with markers were enrolled in this study. Before treatment, all patients were scanned with MV-cone beam computed tomography, and two different calibrations, namely implanted markers-based calibration and skeleton-based calibration, were performed. Finally,a retrospective analysis on the mean differences in left-right, superior-inferior, anterior-posterior directions and 3D spatial vectors was carried out. Results The mean differences between the two calibrations in left-right, superior-inferior, anterior-posterior directions and 3D spatial vectors were 3.2, 6.1, 2.6 and 8.6 mm, respectively. Conclusion In the image-guided radiotherapy for bladder cancer, the accuracy of automatic calibration based on adjacent skeleton is inferior to that of manual calibration based on bladder implanted markers. Avoiding implanted markers, establishing a novel image computational algorithm and exploring a new analysis method are the future trends.

关 键 词：膀胱癌 锥形束CT 图像引导放疗 相邻骨骼 内植标记物 

分 类 号：R812[医药卫生—放射医学]