99mTcO4-唾液腺动态显像评价头颈部肿瘤放射治疗对唾液腺功能的影响  

Evaluation of salivary gland functions in radiotherapy for head and neck tumors by 99mTcO4- dynamic imaging

作　　者：唐武儒[1] 韦嵩[2] 张发恩[2] 韦玲群[1] 赵亮[3] 肖国有[4] TANG Wuru;WEI Song;ZHANG Faen;WEI Lingqun;ZHAO Liang;XIAO Guoyou(Department of Nuclear Medicine, Hechi People's Hospital, Hechi 547000, China;Department of Oncology, Hechi People's Hospital, Hechi 547000, China;Department of Stomatology, Hechi People's Hospital, Hechi 547000, China;Department of Nuclear Medicine, Guangxi Medical University Affiliated Tumor Hospital, Nanning 530021, China)

机构地区：[1]河池市人民医院核医学科,广西河池547000 [2]河池市人民医院肿瘤科,广西河池547000 [3]河池市人民医院口腔科,广西河池547000 [4]广西医科大学附属肿瘤医院核医学科,广西南宁530021

出　　处：《中国医学物理学杂志》2019年第6期701-704,共4页Chinese Journal of Medical Physics

基　　金：河池市科技开发计划(河科转1623-32)

摘　　要：目的:研究99mTcO^-4唾液腺动态显像评价头颈部肿瘤放射治疗对唾液腺功能的影响。方法:应用唾液腺动态显像对2016年3月~2018年9月河池市人民医院收治的80例头颈部肿瘤患者放射治疗前、后的唾液腺摄取和排泌功能的变化进行定量分析,将患者按年龄段分成4组:<30岁、30~40岁、41~51岁,>51岁;病理类型分为3组:鳞状细胞癌、泡状核细胞癌和未分化癌。分析头颈部肿瘤患者性别、年龄、病理类型对放疗后唾液腺功能的影响有无差异。结果:放疗后患侧和健侧唾液腺摄取率与排泄率均比放疗前明显减低,差异有统计学意义(P<0.05)。头颈部肿瘤患者性别、年龄、病理类型对放疗后唾液腺功能的影响无明显差异(P>0.05)。结论:99mTcO^-4唾液腺动态显像能很好地评价放疗对头颈部肿瘤患者唾液腺功能的损害程度。Objective To observe the effects of 99mTcO^-4 dynamic imaging of salivary gland on the evaluation of salivary gland functions in radiotherapy for head and neck tumors. Methods Eighty patients with head and neck tumors who were admitted to Hechi People’s Hospital from March 2016 to September 2018 were enrolled in this study. The uptake and excretion of 99mTcO4- in 80 patients before and after radiotherapy for head and neck tumors were quantitatively analyzed with salivary gland dynamic imaging. According to age(<30 years old, 30-40 years old, 41-51 years old, and >51 years old), the enrolled patients were divided into 4 groups. The pathological types included squamous cell carcinoma, vesicular nuclear carcinoma and undifferentiated carcinoma. Whether gender, age and pathological type of patients with head and neck tumors had different effects on salivary gland functions after radiotherapy was investigated. Results After radiotherapy, the uptake rate and excretion rate of ipsilateral and contralateral salivary glands were significantly lower than those before radiotherapy, with statistical differences(P<0.05).There was no significant difference in the effects of gender, age and pathological type of patients with head and neck tumors on salivary gland functions after radiotherapy(P>0.05). Conclusion 99mTcO^-4dynamic imaging of salivary gland can effectively evaluate the damages to salivary gland functions in patients with head and neck tumors due to static intensity-modulated radiotherapy.

关 键 词：头颈部肿瘤 放射治疗 唾液腺动态显像 唾液腺功能 

分 类 号：R817.4[医药卫生—影像医学与核医学]