早产的发生机制及预测因子新进展  

Recent advance and review of the pathogenesis and predictors of preterm birth

作　　者：付锦娴 陈友鹏[1,2] 陈新 FU Jinxian;CHEN Youpeng;CHEN Xin(Department of Infectious Diseases,the first Affiliated Hospital,Jinan University,Guangzhou 510630;Department of Infectious Diseases,the seventh Affiliated Hospital,Sun Yat-sen University,Shenzhen 518107;Department of Obstetrics,the first Affiliated Hospital,Jinan University,Guangzhou 510630,China)

机构地区：[1]暨南大学附属第一医院感染科,广东广州510630 [2]中山大学附属第七医院感染内科,广东深圳518107 [3]暨南大学附属第一医院产科,广东广州510630

出　　处：《暨南大学学报（自然科学与医学版）》2019年第4期334-338,共5页Journal of Jinan University(Natural Science & Medicine Edition)

基　　金：广东省科技计划基金项目(2014A020212220);广州市科技计划基金项目(201510010027);暨南大学校级重点引智项目(2017-XJZD008)

摘　　要：早产是导致围生儿死亡及新生儿疾病的重要因素,是临床工作中频繁出现的挑战与难题.影响早产的因素众多,生理或心理因素、先天或后天因素都可能在妊娠过程中引致早产.早产的机制更复杂,可能与炎症机制、内分泌系统的调节、母体基因背景等有关.目前临床上预测早产的手段较为局限,综合早产的病因机制及预测因子,查找更多的早产预测因子,为早产的诊断与防治提供依据.Premature birth is a highly risk factor for perinatal death and neonatal diseases.It is a challenge and problem in the clinic.There are many factors affecting preterm birth,such as physical and psychological factors,congenital and acquired diseases.The pathogenesis of preterm birth is complicate,and may be related to inflammation and infection,dysregulation of endocrine system,genetic background,and so on.The methods for predicting preterm birth are limited now.This review has been summarized the etiology and predictors of preterm birth in order to find out the predictors of preterm birth for diagnosis and prevention.

关 键 词：早产 免疫失衡 炎症 蜕膜早衰 预测因子 

分 类 号：R714.7[医药卫生—妇产科学]