不同响度下晚潜伏期响应的锁相值研究  

Investigation for phase-locking value of late latency responses at various loudness scales

作　　者：吴文婷 谭小丹[1] 詹长安[1] WU Wenting;TAN Xiaodan;ZHAN Chang an(School of Biomedical Engineering,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学生物医学工程学院

出　　处：《暨南大学学报（自然科学与医学版）》2019年第4期364-372,共9页Journal of Jinan University(Natural Science & Medicine Edition)

基　　金：广州市科技计划项目(201804010282)

摘　　要：目的:研究听觉诱发电位(AEP)的晚潜伏期响应(LLR)锁相值(PLV)在不同响度下是否表现有差异.方法:对19位听觉正常的成年受试者在响度“most comfortable”和“loud”的脑电信号(EEG)进行扫层分段等预处理后,对各扫层进行6阶复高斯小波变换,选取所有扫层PLV均值最大值对应的时间t和频率f,提取每个扫层在该时刻、频率的相位值并观察2种响度下随扫层数增长的PLV变化差异.结果:频率为2、4、…、30 Hz对应的PLV均值在t约为100 ms时取得最大值,在LLR的N100-P200复合波范围内.在该时刻频率为5 Hz时,50~410扫层“loud”的PLV始终要高于“most comfortable”.取第410扫层的2种响度PLV,检验存在显著性差异(单因素方差分析,P<0.05).结论:LLR在“most comfortable”和“loud”的PLV存在显著差异,可为响度相关的AEP研究提供参考.LLR的PLV有望成为响度客观检测的潜在指标.Objective:To investigate whether the phase-locking values(PLV)of the late latency responses(LLR)in auditory evoked potentials(AEP)might exhibit distinction at various loudness scales.Methods:From 19 adults with normal hearing,the EEG at“most comfortable”and“loud”were recorded respectively and segmented to sweeps.Each sweep was subsequently analyzed using 6 th order complex gaussian wavelet.In each sweep,the phase was calculated at the time and frequency corresponding to the maximum of averaged PLV across all sweeps.Finally,the PLV based on the phase of each sweep was investigated with increasing sweep index at two loudness scales.Results:At 2,4,…,30 Hz,all averaged PLV exhibited their peaks at about 100 ms which is corresponding to the range N100-P200 component of LLR.At 100 ms and 5 Hz,PLV was found to be consistently larger at“loud”than at“most comfortable”from sweep index of 50 th to 410 th.PLV at“most comfortable”showed statistical difference from that at“loud”at sweep index of 410 th(one-way ANOVAL,P<0.05).Conclusion:The PLV of LLR was found to show statistical difference at two loudness scales of“most comfortable”and“loud”,which provides valuably experimental data for the loudness study based on AEP.The PLV of LLR is hopeful to be the potential index of objective loudness metrics.

关 键 词：听觉诱发电位 晚潜伏期响应 响度 锁相值 

分 类 号：R318[医药卫生—生物医学工程]