芬太尼联合咪达唑仑在支气管镜检查中的应用  

Application of combined anesthesia with midazolam and fentanyl in bronchoscopy

作　　者：吴树斌[1] 郑淑梅[1] 陈建永[1] 郑锐林[1] WU Shu-bin;ZHENG Shu-mei;CHEN Jian-yong(Respiratory Department, Chaozhou Center Hospital, Chaozhou, Guangdong 521000, China)

机构地区：[1]潮州市中心医院呼吸内科

出　　处：《中国处方药》2019年第7期14-16,共3页Journal of China Prescription Drug

基　　金：潮州市卫生和计划生育局科研项目(潮卫科研201806)

摘　　要：目的探讨芬太尼联合咪达唑仑在支气管镜检查中的应用价值。方法选自2016年1月~2019年1月期间在潮州市中心医院进行支气管镜检查的120例患者为观察对象,根据麻醉方式的不同分为观察组(芬太尼联合咪达唑仑麻醉)和对照组(单一使用咪达唑仑麻醉),每组60例。观察两组患者麻醉后的血流动力学指标及血氧饱和度的变化,分析两组患者术后的咳嗽、疼痛及术后遗忘的程度和术后并发症的发生率,并比较两组患者的术后满意度。结果观察组术中低血压、心动过缓以及低氧血症的发生率低于对照组,差异有统计学意义(P<0.05)。与对照组相比,观察组患者术中咳嗽、疼痛的视觉模拟评分明显降低(P<0.05),术后遗忘程度高及并发症少(P<0.05)。观察组的术后满意度明显高于对照组(P<0.05)。结论在支气管镜检查中,应用芬太尼与咪达唑仑的联合用药方案不仅能提高药物的安全性,还能减少药物带来的毒副反应,具有独特的临床应用优势。Objective To explore the application value of combined anesthesia with midazolam and fentanyl in bronchoscopy. Methods A total of 120 patients admitted to the hospital from January 2016 to January 2019 were recruited into this study, and they were randomly divided into observation group (midazolam combined with fentanyl) and control group( midazolam anesthesia alone), and 60 patients in each group. Then, the fluctuations of the hemodynamoc parameters and the oxygen saturation of patients in two groups were monitored during the operation. Subsequently, the degree of the intraoperative frequent cough and intraoperative pain, the postoperative amnesia rate and the postoperative complication rate as well as the postoperative satisfaction rate were compared between the two groups. Results The incidence rate of intraoperative hypotension, intraoperative bradycardia and intraoperative hypoxia were lower than that in the control group( P < 0.05). In addition, the degree of the intraoperative frequent cough and intraoperative pain evaluated by the Visual Analogue Score in patients of the observation group were significantly lower than that of the control group( P < 0.05). Moreover, compared with the control group, patients of the observe group had higher postoperative amnesia rate and little postoperative complication rate, as well as higher postoperative satisfaction rate( P < 0.05). Conclusion The combined anesthesia with midazolam and fentanyl can improve the safety and reduce the occurrence of side-effects in bronchoscopy, which is worth of clinical application.

关 键 词：芬太尼 咪达唑仑 支气管镜 麻醉 

分 类 号：R768.1[医药卫生—耳鼻咽喉科]