人滋养层细胞侵袭力分子调节机制研究  

Study on Molecular Regulation Mechanism of Human Trophoblast Cell Invasiveness

作　　者：黎陈 陈指龙 范秀军[2] 杨青[1] LI Chen;CHEN Zhi-Long;FAN Xiu-Jun;YANG Qing(College of Veterinary Medicine,Hunan Agricultural University,Changsha 410128,Hunan,China;Reproductive Health Laboratory,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,Guangdong,China)

机构地区：[1]湖南农业大学动物医学院,湖南长沙410128 [2]中国科学院深圳先进技术研究院生殖健康实验室,广东深圳518055

出　　处：《医学信息》2019年第13期21-24,共4页Journal of Medical Information

基　　金：国家自然科学基金(编号:31572591,81571445);湖南省自然科学基金杰出青年项目(编号:2015JJ1009)

摘　　要：胎盘是妊娠过程中形成的暂时性的特异器官,它在母体和胎儿间起着重要的桥梁作用。滋养层细胞具有类似于肿瘤细胞迁移和浸润的能力,作为胎盘组织的主要组成细胞之一,在胚胎植入、胎盘的形成和发育等许多生理过程中发挥着重要的作用,但同时也是多种毒素和病原微生物入侵时的靶细胞。滋养细胞侵入过度将导致绒毛膜癌等疾病的发生,浸润不足则可能造成流产、子痫前期等妊娠期疾病。目前,诸多研究表明在胎盘形成过程中,有许多分子和信号通路参与对其滋养层细胞的调控,但滋养层细胞迁移与浸润的具体机制尚不完全明确。本文对人滋养层细胞侵袭力分子调节机制进行了系统论述,旨在为研究病理性妊娠的发生、发展过程提供参考。The placenta is a temporary specific organ formed during pregnancy, which plays an important role as a bridge between the mother and the fetus. Trophoblast cells have the ability to migrate and infiltrate tumor cells. As one of the main components of placental tissue, trophoblast cells play an important role in many physiological processes such as embryo implantation, placental formation and development, but also a variety of Target cells when toxins and pathogenic microorganisms invade. Invasion of trophoblasts will lead to diseases such as choriocarcinoma. Insufficient infiltration may cause diseases such as abortion and pre-eclampsia. At present, many studies have shown that many molecules and signaling pathways are involved in the regulation of trophoblast cells during placental formation, but the specific mechanism of trophoblast cell migration and infiltration is not completely clear. In this paper, the molecular regulation mechanism of human trophoblast cell invasiveness is systematically discussed, which is helpful to study the occurrence and development of pathological pregnancy.

关 键 词：人滋养层细胞 细胞迁移 细胞浸润 胎盘 

分 类 号：R714.2[医药卫生—妇产科学]