不同分型腺性膀胱炎中CK20、Ki67、Ras P21蛋白表达及临床意义研究  

Expression of CK20,Ki67 and Ras P21 Proteins in Different Types of Glandular Cystitis and Clinical Significance

作　　者：王洪志 杨林 熊波 罗军 WANG Hong-zhi;YANG Lin;XIONG Bo;LUO Jun(Department of Urology,People's Hospital of Bishan District,Chongqing 402760,China)

机构地区：[1]重庆市璧山区人民医院泌尿外科

出　　处：《医学信息》2019年第13期94-96,共3页Journal of Medical Information

基　　金：重庆市卫生局医学科学技术研究面上资助项目(编号:2011-2-569)

摘　　要：目的探讨CK20、Ki67、RasP21蛋白三种肿瘤标志物在正常膀胱组织、不同类型腺性膀胱炎及膀胱腺癌组织中表达的特点。方法将腺性膀胱炎经典型(泌尿上皮型)20例、肠上皮型20例、前列腺上皮型20例,正常膀胱组织20例、膀胱腺癌组织20例,采用免疫组织化学法,检查CK20、Ki67、RasP21在各分型腺性膀胱炎中的表达,并与正常膀胱组织、膀胱腺癌组织组进行比较。结果肠上皮型和前列腺上皮型腺性膀胱炎CK20、Ki67、RasP21阳性表达与正常膀胱黏膜组织比较,差异具有统计学意义(P<0.05)。而经典型(泌尿上皮型)CK20、Ki67、RasP21的表达与正常膀胱黏膜组织比较,差异无统计学意义(P>0.05),肠上皮型和前列腺上皮型腺性膀胱炎及膀胱腺癌中CK20、Ki67、RasP21高表达。肠上皮型和前列腺上皮型腺性膀胱炎可能为癌前病变。结论对于肠上皮型及前列腺型腺性膀胱炎,应进行积极的手术治疗及抗癌药物膀胱灌注,并严密术后随访。Objective To investigate the expression of three tumor markers of CK20, Ki67 and Ras P21 in normal bladder tissues, different types of glandular cystitis and bladder adenocarcinoma. Methods 10 cases of classic cystitis (urinary epithelial type), 10 cases of intestinal epithelium, 10 cases of prostate epithelium, 10 cases of normal bladder tissue and 10 cases of bladder adenocarcinoma were examined by immunohistochemistry. The expression of Ki67 and Ras P21 in each glandular cystitis was compared with normal bladder tissue and bladder adenocarcinoma.Results The positive expressions of CK20, Ki67 and Ras P21 in intestinal epithelial type and prostatic epithelial glandular cystitis were significantly different from those in normal bladder mucosa (P<0.05). The expression of classic (urinary epithelial) CK20, Ki67, Ras P21 was not significantly different from normal bladder mucosa (P>0.05), intestinal epithelial and prostatic epithelial cystitis and bladder adenocarcinoma. CK20, Ki67, and Ras P21 are highly expressed. Intestinal epithelial and prostatic epithelial glandular cystitis may be precancerous lesions.Conclusion For intestinal epithelial and prostatic glandular cystitis, active surgical treatment and anti-cancer drug bladder infusion should be performed and followed up closely.

关 键 词：腺性膀胱炎 分型 CK20 KI67 RASP21 

分 类 号：R694.3[医药卫生—泌尿科学]