温州地区献血者隐匿性乙型肝炎流行病学特征  

Epidemiological characteristics of occult hepatitis B infection from blood donors in Wenzhou area

作　　者：张琼[1] 张锋[1] 蔡淑锋[1] 朱紫苗 刘燕飞[1] 徐伟瑞 Zhang Qiong;Zhang Feng;Cai Shufeng;Zhu Zimiao;Liu Yanfei;Xu Weirui(Central Blood Station of Wenzhou,Wenzhou 325000,Zhejiang,China)

机构地区：[1]温州市中心血站,浙江温州325000

出　　处：《国际流行病学传染病学杂志》2019年第3期228-230,共3页International Journal of Epidemiology and Infectious Disease

基　　金：温州市医药卫生科研项目(2015B17).

摘　　要：目的分析温州地区隐匿性乙型肝炎(OBI)献血者流行病学特征,为无偿献血招募对象的选择提供依据。方法收集2014年10月至2015年10月温州地区无偿献血者样本60 758份,采用血清学、核酸检测技术对HBV、HCV、HIV感染标志物进行检测,并对献血者按性别、年龄、学历、献血次数分组比较OBI检出情况。结果60 758例无偿献血者中检出80例OBI患者。男性无偿献血者OBI阳性率明显高于女性(χ^2=14.04,P<0.05);不同年龄组OBI阳性率比较差异有统计学意义(χ^2=43.82,P<0.05),其中46~55岁年龄组阳性率最高为0.79%;高学历组阳性率明显低于低学历组(χ^2=8.87,P<0.05)。不同献血次数组间比较差异无统计学意义(P>0.05)。结论温州地区献血者OBI以男性、高年龄段为主。献血者招募征询过程中可以鼓励低年龄段、高学历女性成员成为固定无偿献血者,可有效降低OBI携带的风险。Objective To investigate the epidemiological characteristics of occult hepatitis B infection blood donors in Wenzhou, so as to provide a basis for voluntary blood donation recruitment. Methods Blood specimens from 60 758 blood donors in Wenzhou area were collected during October 2014 and October 2015. HBV, HCV and HIV infection markers were detected by serology and nucleic acid testing, and occult hepatitis B infection detection was compared by gender, age, education background and times of blood donation. Results Among 60 758 blood specimens collected from volunatary donors, there were 80 occult hepatitis B infection cases. The positive rate of occult hepatitis B infection in male group was significantly higher than that in female group (χ^2=14.04, P<0.05). The positive rates of occult hepatitis B infection in different age groups were significantly different (χ^2=43.82, P<0.05), and 46-55 age group was the highest (0.79%). The positive rate in highly educated group was significantly lower than that in the low degree group (χ^2=8.87, P<0.05). There was no significant difference in blood donors with different donor time (P>0.05). Conclusions The blood donors with occult hepatitis infection are mainly males and of old age in Wenzhou. During the recruitment and solicitation process of blood donors, females at younger age and with higher education can be encouraged to become unpaid blood donors, which can effectively reduce the risk of occult hepatitis B infection.

关 键 词：肝炎 乙型 血清学 核酸检测 献血员招募 

分 类 号：R512.62[医药卫生—内科学]