基于数据挖掘分析易无庸教授治疗慢性肾衰随诊6年中药处方  

Analysis of Traditional Chinese Medicine Prescription for Chronic Renal Failure Following-up 6 Years by Professor Yi Wuyong: Based on Data Mining

作　　者：陈志红 卢春键 袁常健 蔡玉纯 易无庸[2] Chen Zhihong;Lu Chunjian;Yuan Chanjian;Chai Yuchun;Yi Wuyong(The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine,Shenzhen 518000,China;Shenzhen Traditional Chinese Medicine Hospital Affiliated to Guangzhou University of Traditional Chinese Medicine,Shenzhen 518000,China)

机构地区：[1]广州中医药大学第四临床医学院,深圳518000 [2]广州中医药大学附属深圳市中医院,深圳518000

出　　处：《世界中医药》2019年第6期1598-1601,共4页World Chinese Medicine

基　　金：2018年度深圳市卫生系统科研项目(SZXJ2018006)

摘　　要：目的:基于数据挖掘技术回顾性分析易无庸教授治疗慢性肾衰竭随诊6年中药处方用药规律。方法:收集2012年1月至2018年8月于易无庸教授门诊处随诊6年的慢性肾衰患者所开具的中药处方及门诊病例资料,通过Python进行一维及二维的数据分析、运用FP-growth算法得出频次前1000的多维数据分析;使用Gephi软件分层可视化网络图,总结出用药规律及特点。结果:处方中,共用到中药饮片267味,使用频率最高的中药为黄芪(97.0%);用药结构分析显示,药性方面温药(41.0%)、寒药(36.0%)使用频率最高;药味方面甘味药(32.4%)、苦味药(30.2%)使用频率最高;药性归经方面入肝经之药(19.4%)使用频率最高;药物类别方面补虚药(50.9%)使用频率最高,其次为活血药(17.7%)。三维、四维分析组合最高的分别是黄芪、牡丹皮、麸炒枳实;黄芪、牡丹皮、麸炒枳实、熟大黄;黄芪、牡丹皮、麸炒枳实、熟大黄、熟地黄。结论:易无庸教授在慢性肾功能衰竭长期治疗上用药主要遵循寒温并用,甘苦共调,益气扶正、补肾活血、疏肝理气、通腑泄浊、健脾祛湿之法,与中医治疗理论相匹配,可为慢性肾衰竭的中药治疗提供参考。Objective: To retrospectively analyze the rule of prescription of traditional Chinese medicine(TCM)in chronic renal failure(CRF)with 6 years follow-up treated by Professor Yi Wuyong based on data mining technique. Methods: From January 2012 to August 2018,the prescriptions of traditional Chinese medicine and the data of outpatient cases were collected from the outpatient department of Professor Yi Wuyong for 6 years,and the data of one dimension and two dimensions were analyzed by Python.The FP-growth algorithm was used to get the frequency of the first 1 000 multidimensional data analysis;Gephi software was used to visualize the network diagram,the law and characteristics of drug use were summarized. Results: In the prescription,267 kinds of Chinese medicine pieces were used.The most frequently used Chinese medicine was Radix Astragali seu Hedysari(97.0%),the structure analysis showed that the property of warm medicine(41.0%)and the cold medicine(36.0%)were the most frequently used.In the flavor aspect,sweet medicine(32.4%)and bitter medicine(30.2%)were used most frequently.In the channel tropism,the medicine into the liver channel(19.4%)was the most frequently used.The drugs of tonifying deficiency(50.9%)were the most frequently used,followed by blood activating drugs(17.7%).The highest three dimensional and four dimensional analysis combinations were Radix Astragali seu Hedysari,Cortex Moutan Radicis,fried Fructus Aurantii Immaturus;Radix Astragali seu Hedysari,Cortex Moutan Radicis,fried Fructus Aurantii Immaturus,Radix et Rhizoma Rhei;Astragali seu Hedysari,Cortex Moutan Radicis,fried Fructus Aurantii Immaturus,Radix et Rhizoma Rhei,Radix Rehmanniae Preparata. Conclusion: Professor Yi Wuyong′s treatment of chronic renal failure is mainly in accordance with the combination of cold and warm,adjustment of sweet and bitter,tonifying qi and strengthening healthy qi,invigorating the kidney and promoting blood circulation,soothing the liver and regulating qi,dredging viscera and removing turbidity,invigorating sp

关 键 词：数据挖掘 慢性肾衰 中药处方 用药分析 @易无庸 随诊 

分 类 号：R256.5[医药卫生—中医内科学]