血清卵磷脂胆固醇酰基转移酶活性与冠心病的关系  

Association between lecithin:cholesterol acyltransferase activity and coronary artery disease

作　　者：王玉 于雪[2] 张闻多[2] 王欣越[2] 杨睿悦[1] 王思明[1] 曾洁[3] 唐月明 栗向辉 李红霞[1] 陈文祥[3] 董军[1] 季福绥[2] Wang Yu;Yu Xue;Zhang Wenduo;Wang Xinyue;Yang Ruiyue;Wang Siming;Zeng Jie;Tang Yueming;Li Xianghui;Li Hongxia;Chen Wenxiang;Dong Jun;Ji Fusui(Laboratory of Biochemistry and Molecular Biology, Beijing Hospital, National Center of Gerontology, Beijing 100730, China;Department of Cardiology, Beijing Hospital, National Center of Gerontology, Beijing 100730, China;National Center for Clinical Laboratories, Beijing 100730, China)

机构地区：[1]北京医院生物化学与分子生物室,国家老年医学中心,100730 [2]北京医院心内科,100730 [3]卫生部临床检验中心,北京100730

出　　处：《中国心血管杂志》2019年第3期205-208,共4页Chinese Journal of Cardiovascular Medicine

基　　金：国家自然科学基金项目(81472035、81171647)~~

摘　　要：目的探讨血清卵磷脂胆固醇酰基转移酶活性(LCAT)与冠心病(CAD)的关系。方法本研究为病例对照研究。纳入2014年11月至2015年8月在北京医院行冠脉造影的425例患者,按冠状动脉造影结果分为CAD组(341例)和非CAD对照组(84例),应用高效液相色谱法测定血清LCAT活性,分析LCAT活性与CAD及其他危险因素的关系。结果CAD组中LCAT活性显著高于非CAD组[(37.3±9.7)nKat/L比(34.8±8.8)nKat/L,P=0.03],两组的高密度脂蛋白胆固醇、ApoAI和随机血糖等均有显著差异(均为P<0.05)。Spearman相关性分析显示,LCAT活性与体质指数(r=0.09)、TG(r=0.30)、ApoB(r=0.22)和随机血糖(r=0.09)呈正相关;与HDL-C(r=-0.26)呈负相关(均为P<0.05)。单因素logistic回归分析结果显示,LCAT活性升高是CAD危险因素(OR=3.11,95%CI:1.40~6.91,P=0.005),在校正年龄、性别、HDL-C、ApoAI、随机血糖等危险因素后,多因素logistic回归分析发现LCAT的活性升高仍是CAD危险因素(OR=3.28,95%CI:1.27~8.50,P=0.014)。结论LCAT活性升高与冠心病独立相关,但仍需更多研究证实。Objective To assess the relationship between serum lecithin: cholesterol acyltransferase (LCAT) activity and angiographically defined coronary artery disease (CAD). Methods This study is a case-control study. A total of 425 hospitalized patients underwent coronary angiography in Beijing Hospital from November 2014 to August 2015 were included. Patients were divided into CAD group ( n =341) and non-CAD control group ( n =84) according to coronary angiogram results. Serum LCAT activities were determined by high performance liquid chromatography , and the relationship between LCAT activity and CAD and other risk factors was analyzed. Results Serum LCAT activities were significantly higher in CAD group than in non-CAD control group [(37.3±9.7)nKat/L vs.(34.8±8.8)nKat/L, P =0.03]. There were significant differences in high density lipoprotein cholesterol (HDL-C), ApoAI and glucose (all P <0.05). Correlation analyses showed that LCAT activities were positively correlated with body mass index ( r =0.09), triglyceride ( r =0.30), ApoB ( r =0.22) and glucose ( r =0.09), and negatively correlated with HDL-C ( r =-0.26)(all P <0.05). The single factor logistic regression analysis showed that LCAT activity was an independent risk factor for CAD ( OR =3.11, 95% CI : 1.40-6.91, P =0.005). After adjusted for age, gender, HDL-C, ApoAI, and glucose, LCAT activity was independently positively correlated with CAD ( OR =3.28, 95% CI : 1.27-8.50, P =0.014). Conclusions Elevated serum LCAT activity is independently associated with angiographically defined CAD, but more research is needed.

关 键 词：胆固醇卵磷脂酰基转移酶 冠状动脉疾病 危险因素 

分 类 号：R541.4[医药卫生—心血管疾病]