左西孟旦在急性前壁心肌梗死合并心力衰竭患者中的应用  

Application of levosimendan in acute anterior myocardial infarction patients complicated with heart failure

作　　者：王芳[1] 徐承义[1] 刘心甜[1] 吴明祥[1] 刘成伟[1] 苏晞[1] Wang Fang;Xu Chengyi;Liu Xintian;Wu Mingxiang;Liu Chengwei;Su Xi(Department of Cardiology, Wuhan Asia Heart Hospital, Wuhan 430022, China)

机构地区：[1]武汉亚洲心脏病医院心内科

出　　处：《中国心血管杂志》2019年第3期245-249,共5页Chinese Journal of Cardiovascular Medicine

基　　金：武汉亚洲心脏病医院创新基金项目(2015CX3-A03)~~

摘　　要：目的评估直接经皮冠状动脉介入(PPCI)术后急性ST段抬高型心肌梗死(STEMI)合并心力衰竭患者应用左西孟旦的有效性和安全性。方法连续纳入2015—2016年武汉亚洲心脏病医院急性前壁心肌梗死PPCI围术期(72h)出现急性左心衰竭(包括心原性休克)的患者87例,按照随机数字表法分为研究组(左西孟旦治疗,44例)和对照组(标准药物治疗,43例),主要终点为呼吸困难评分。结果两组的年龄、性别、病史、实验室检查和心功能等基线资料相似,但研究组的中位肌钙蛋白I峰值显著高于对照组(90.8μg/L比58.5μg/L,χ^2=2.098,P=0.042)。与对照组比较,研究组患者治疗后的呼吸困难评分从第3天开始显著改善(P<0.05)、N末端B型利钠肽原第5天显著下降[(3184.0±1573.0)ng/L比(5063.0±1938.0)ng/L,χ^2=2.398,P=0.021]。6个月随访时,两组的心原性死亡与因心力衰竭再次住院复合事件发生率无显著差异(29.5%比37.2%,χ^2=0.575,P=0.448),但研究组的低血压发生率明显高于对照组(39.5%比18.6%,χ^2=4.261,P=0.039)。两组的药物安全性事件发生率相似(P>0.05)。结论左西孟旦能安全、有效、快速地改善PPCI术后急性前壁心肌梗死合并心力衰竭患者的呼吸困难症状,但不能减少6个月复合临床终点事件,且需注意监测血压。Objective To evaluate the efficacy and safety of levosimendan in patients with acute ST-segment elevation myocardial infarction (STEMI) complicated with heart failure undergoing primary percutaneous coronary intervention (PPCI). Methods A total of consequent 87 patients with acute anterior STEMI patients with heart failure within 72 h during peri-operative period of PPCI (including cardiogenic shock) were enrolled from 2015 to 2016 in Wuhan Asia Heart Hospital. The participants were randomly assigned to levosimendan group (study group, 44 cases) or optimal medication group (43 cases). The primary endpoint was dyspnea score. Results Baseline data such as age, sex, history, laboratory data and cardiac function were similar in the two groups. The median troponin I (TnI) was significantly higher in study group (90.8μg/L vs. 58.5μg/L,χ^2 =2.098, P=0.042). Compared with control group, the study group had a significant improvement in the dyspnea score ( P <0.05), and the N-terminal B-type natriuretic peptide decreased significantly [(3 184.0±1 573.0)ng/L vs.(5 063.0±1 938.0)ng/L,χ^2 =2.398, P =0.021]. At 6-month follow up, composite outcome (cardiac death and re-hospitalization for heart failure) in the study group was similar with the control group (29.5% vs. 37.2%,χ^2 =0.575, P =0.448). Hypotension incidence was significantly higher in the study than control group (39.5% vs. 18.6%,χ^2 =4.261, P =0.039). The incidence of drug safety events was similar between the two groups ( P >0.05). Conclusions Levosimendan may improve symptom of dyspnea in PPCI-treated anterior STEMI patients complicated with heart failure, but can not reduce the 6-month composite clinical endpoint, and should pay attention to monitoring blood pressure.

关 键 词：左西孟旦 冠状动脉疾病 血管成形术 经皮 经冠状动脉 心力衰竭 

分 类 号：R542.22[医药卫生—心血管疾病]