左西孟旦对老年急性心力衰竭患者心脏功能MACE事件及不良反应的影响  

Effect of levosimendan on cardiac function,MACE events and adverse reactions in elderly patients with acute heart failure

作　　者：孙飞 王海珠[1] 刘丹丹[1] 郁华[1] 冉华中[1] 张军堂[1] SUN Fei;WANG Haizhu;LIU Dandan(Department of Cardiology,Zhoukou Central Hospital,Zhoukou 466000,China)

机构地区：[1]河南省周口市中心医院心内一科

出　　处：《安徽医学》2019年第6期621-624,共4页Anhui Medical Journal

摘　　要：目的分析左西孟旦对老年急性心力衰竭患者心脏功能、不良心脏(MACE)事件及不良反应的影响。方法选取2017年1月至2018年7月周口市中心医院心内科收治的老年急性心力衰竭患者64例,按随机数字表法分为对照组与观察组,每组各32例。对照组采取常规治疗方案,观察组在常规治疗基础上加用左西孟旦治疗。观察两组患者治疗前、治疗1周后B型脑钠肽(BNP)、心脏功能指标(LVEF、SV、LVESD、LVEDD)、MACE事件(心力衰竭、恶性心律失常、心源性死亡)及不良反应情况。结果治疗1周后,观察组BNP治疗前后差值较对照组高,差异有统计学意义(P<0.05);观察组LVEF、SV、LVESD、LVEDD治疗前后差值较对照组高,差异有统计学意义(P<0.05);观察组MACE事件的发生率为37.5%,低于对照组的65.6%;观察组不良反应率为9.38%,低于对照组的62.5%,差异均有统计学意义(P<0.05)。结论左西孟旦治疗老年急性心力衰竭可有效改善患者心脏功能,减少MACE事件与不良反应的影响。Objective To investigate the effect of levosimendan on cardiac function,MACE events and adverse reactions in elderly patients with acute heart failure. Methods From January 2017 to July 2018,64 cases of elderly patients with acute heart failure treated in the Cardiovascular Department of Zhoukou Central Hospital were selected and equally divided into two groups according to the admission order.The control group received routine treatment,while the observation group received the levosimendan based on routine treatment.The efficacy of two groups before treatment and one week after treatment,cardiac function changes (LVESD,LCEDD),MACE events (heart failure ,malignant arrhythmia,cardiac death,total MACE events) and adverse reactions (blood pressure reduction,arrhythmia,headache) were observed. Results There was significant difference in BNP as well as LVEF,SV LVESD and LVEDD differentials between the two groups before treatment and one week after treatment ( P <0.05).The incidence of MACE events in observation group was 37.5%,lower than 65.6% in control group,and the rate of adverse reactions in observation group was 9.38%,lower than 62.5% in control group,and the difference was statistically significant ( P <0.05). Conclusions Levosimendan can effectively ameliorate the cardiac function of patients and reduce the effects of MACE events and adverse reactions in elderly patients with acute heart failure.

关 键 词：左西孟旦 老年急性心力衰竭 心脏功能 MACE事件 不良反应 

分 类 号：R541.6[医药卫生—心血管疾病]