CO2激光联合不同剂量干扰素治疗尖锐湿疣临床疗效研究  

Clinical Efficacy of CO2 Laser Combined with Different Doses of Interferon in the Treatment of Condyloma Acuminatum

作　　者：沈秀兰[1] SHEN Xiu-lan(Department of Dermatology,First Hospital of Danjiangkou,Danjiangkou 442700,Hubei,China)

机构地区：[1]丹江口市第一医院皮肤科

出　　处：《中国美容医学》2019年第7期51-55,共5页Chinese Journal of Aesthetic Medicine

摘　　要：目的:探究二氧化碳(CO2)激光联合不同剂量干扰素治疗尖锐湿疣(CA)的临床疗效。方法:回顾性分析82例行CO2激光治疗的CA患者临床资料,根据不同干扰素封闭注射给药剂量分为大剂量组(3×106IU/次,n=28)、小剂量组(1×106IU/次,n=31)与对照组(未给予干扰素,n=23)。比较激光治疗前及治疗后4周,三组外周血免疫细胞分布[CD3^+、CD4^+/CD8^+、自然杀伤(NK)细胞]、白细胞介素[白细胞介素-2(IL-2)、白细胞介素-10(IL-10)、白细胞介素-12(IL-12)]、功能性细胞因子[淋巴细胞趋化因子(LTN)、巨噬细胞移动抑制因子(MIF)、粒细胞-巨噬细胞集落刺激因子(GMCSF)]水平变化,分析三组激光治疗后4周时治疗效果、激光治疗后3个月内复发率,及两组用药患者给药疗程内的药物不良反应发生情况。结果:激光治疗后4周,三组外周血CD3^+水平均较激光治疗前显著提升(P<0.05),但组间同一时间CD3^+水平比较均无统计学意义(P>0.05);三组外周血CD4^+/CD8^+、NK细胞及血清IL-2、IL-12、LTN水平均较激光治疗前显著提升,且同一时间比较大剂量组>小剂量组>对照组(P<0.05);三组血清IL-10、MIF、GM-CSF水平均较激光治疗前显著下降,其同一时间比较大剂量组<小剂量组<对照组(P<0.05);大剂量组与小剂量组治疗有效率均明显高于对照组(P<0.05)。激光治疗后3个月内,大剂量组与小剂量组复发率均明显低于对照组(P<0.05)。给药疗程内,大剂量组药物不良反应总发生率明显高于小剂量组(P<0.05)。结论:CO2激光联合干扰素封闭注射治疗CA能取得较为理想的临床效果,且疗效与复发率不受给药剂量影响,采取小剂量给药方案安全性更突出,有利于患者预后及康复。Objective To investigate the clinical effects of carbon dioxide (CO2) laser combined with different doses of interferon in the treatment of condyloma acuminatum (CA). Methods The clinical data of 82 patients with CA who underwent CO2 laser treatment were retrospectively analyzed. According to the different administration doses of interferon-blocked injection, the patients were divided into high-dose group (3×106 IU/time, n =28) and low-dose group (1×10^6 IU/ time, n =31) and control group (not given interferon, n =23). The levels of peripheral blood immune cell distribution [CD3^+, CD4^+/CD8^+, natural killer (NK) cells], interleukins [interleukin-2 (IL-2), interleukin-10 (IL-10), interleukin-12 (IL-12)] and functional cytokines [lymphocyte chemotactic factor (LTN), macrophage migration inhibitory factor (MIF), granulocyte-macrophagocyte colony-stimulating factor (GM-CSF)] were compared among the three groups before laser treatment and at 4 weeks after laser treatment. The treatment effects at 4 weeks after laser treatment, the recurrence rate within 3 months after laser treatment, and the occurrence of adverse drug reactions during the course of treatment were analyzed among the three groups. Results At 4 weeks after laser treatment, the CD3^+ level in peripheral blood in the three groups was significantly higher than that before laser treatment (P <0.05), but there was no significant difference in CD3^+ level between the groups at the same time (P >0.05). The levels of peripheral blood CD4^+/CD8^+, NK cells and serum IL-2, IL-12 and LTN in the three groups were significantly higher than those before laser treatment, and the levels at the same time showed high-dose group>low-dose group>control group (P <0.05). The levels of serum IL-10, MIF and GM-CSF in the three groups were significantly lower than those before laser treatment, and the levels at the same time showed high-dose group<low-dose group<control group (P <0.05). The effective rate of treatment in high-dose group and low-dose group was significantly

关 键 词：CO2激光 干扰素 给药剂量 尖锐湿疣 复发 免疫细胞 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]