痰嗜酸粒细胞、25（OH）D3、FeNO检测在ACOS疾病诊断中的应用价值  

Detection of induced sputum eosinophils, 25(OH) D3 and FeNO in diagnosis of ACOS disease

作　　者：李莉[1] 赵静[1] LI Li;ZHAOJing(Department of Respiratory, the First Hospital Yulin City, Shaanxi Province, Yulin 719000,China)

机构地区：[1]陕西省榆林市第一医院呼吸内科

出　　处：《中国医药导报》2019年第16期100-103,共4页China Medical Herald

基　　金：陕西省榆林市科技计划项目(2014yyws-05)

摘　　要：目的分析诱导痰嗜酸粒细胞、25-羟基维生素D3[25(OH)D3]、呼出气一氧化氮(FeNO)在哮喘-慢性阻塞性肺疾病重叠综合征(ACOS)疾病诊断中的意义。方法选取陕西省榆林市第一医院2016年1月~2018年5月50例确诊为ACOS患者作为观察组,50例慢性阻塞性肺疾病患者作为对照组。分析各组痰嗜酸粒细胞、25(OH)D3、FeNO水平,并绘制ROC曲线分析各指标诊断价值。结果观察组患者嗜酸粒细胞及25(OH)D3水平均低于对照组(P <0.05),且观察组患者FeNO水平高于对照组,差异有统计学意义(P <0.05);观察组患者嗜酸粒细胞、25(OH)D3及FeNO阳性率均高于对照组,差异有统计学意义(P <0.05);且FeNO诊断的灵敏度高于25(OH)D3(P <0.05),且其特异度高于嗜酸粒细胞(P <0.05),ROC曲线下面积高于25(OH)D3(P <0.05)。结论采用痰嗜酸粒细胞、25(OH)D3、FeNO对ACOS疾病进行诊断时具有较高的应用价值,但FeNO诊断价值明显高于痰嗜酸粒细胞和25(OH)D3。Objective To analyze the significance of induced sputum eosinophils, 25-hydroxyvitamin D [25 (OH) D3] and exhaled nitric oxide (FeNO) in the diagnosis of asthma-copd overlap syndrome (ACOS). Methods From January 2016 to May 2018, 50 patients diagnosed with ACOS in the First Hospital of Yulin City, Shaanxi Province were selected as the observation group and 50 patients with chronic obstructive pulmonary disease as the control group, the levels of phlegm eosinophils, 25(OH) D3 and FeNO in each group were analyzed, and ROC curves were drawn to analyze the diagnostic value of each index. Results The levels of eosinophil and 25 (OH) D3 in the observation group were lower than those in the control group (P < 0.05), and FeNO level in the observation group was higher than that in the control group (P < 0.05). The positive rates of eosinophil, 25 (OH) D3 and FeNO in the observation group were all higher than those in the control group, with statistically significant differences (P < 0.05). In addition, the sensitivity of FeNO diagnosis was higher than 25 (OH) D3 (P < 0.05), the specificity was higher than that of eosinophil (P < 0.05), and the area under the ROC curve was higher than 25 (OH) D3 (P < 0.05). Conclusion The use of phlegm eosinophils, 25 (OH) D3 and FeNO in the diagnosis of ACOS disease has a high application value, but the diagnostic value of FeNO is significantly higher than that of phlegm eosinophils and 25 (OH) D3.

关 键 词：痰嗜酸粒细胞 25-羟基维生素D3 呼出气一氧化氮 哮喘-慢性阻塞性肺疾病重叠综合征 

分 类 号：R562.2[医药卫生—呼吸系统]