葡萄糖酸钙锌口服溶液佐治小儿轻度腹泻45例临床观察  

Clinical Observation on Calcium and Zinc Gluconates Oral Solution in the Adjuvant Treatment of 45 Children Patients with Mild Diarrhea

作　　者：武金霞[1] 马保海[1] 王执勇[1] 孙爱玲[1] 颜文娟 郭辉[1] WU Jinxia;MA Baohai;WANG Zhiyong;SUN Ailing;YAN Wenjuan;GUO Hui(Department of Child Health Care,Weifang Maternal and Child Health Hospital,Weifang,Shandong,China 261011)

机构地区：[1]山东省潍坊市妇幼保健院儿童保健科

出　　处：《中国药业》2019年第14期53-55,共3页China Pharmaceuticals

基　　金：山东省潍坊市卫生计生委科研项目[2017wsjs009]

摘　　要：目的探讨葡萄糖酸钙锌口服溶液佐治轻度腹泻患儿的临床疗效及对心肌酶的影响。方法选取医院2015年6月至2017年7月收治的轻度腹泻患儿90例,按随机数字表法分为对照组和观察组,各45例。两组患儿均采用补液、平衡电解质、营养支持、脱水、纠正酸中毒及抗感染等常规方法治疗,在此基础上,对照组患儿口服蒙脱石散治疗,观察组患儿口服葡萄糖酸钙锌口服溶液治疗,均治疗14d。结果观察组总有效率为93.33%,明显高于对照组的82.22%(P<0.05);观察组治疗后乳酸脱氢酶、肌酸激酶、肌酸激酶同工酶、肿瘤坏死因子-α、白细胞介素6及白细胞介素10水平均明显下降,且观察组均明显低于对照组(P<0.05);两组患儿不良反应发生率相当(4.44%比6.67%)。结论葡萄糖酸钙锌口服溶液佐治小儿轻度腹泻,有助于增强临床疗效,改善心肌酶及炎性因子水平。Objective To investigate the clinical efficacy of Calcium and Zinc Gluconates Oral Solution in the adjuvant treatment of children patients with mild diarrhea and its effect on myocardial enzymes.Methods Totally 90 children patients with mild diarrhea admitted to our hospital from June 2015 to July 2017 were selected and divided into the control group and the observation group according to the random number table method,45 cases in each group.The children patients in the two groups were treated with routine methods such as fluid replacement,balanced electrolyte,nutritional support,dehydration,acidosis correction and anti-infection.On this basis,the children patients in the control group took Montmorillonite Powder orally,while the children patients in the observation group took Calcium and Zinc Gluconates Oral Solution orally.Both groups were treated for 14 d.Results The total effective rate of the observation group was 93.33%,which was significantly higher than 82.22%of the control group(P<0.05).The levels of lactate dehydrogenase(LDH),creatine kinase(CK)and creatine kinase isoenzyme(CK-MB),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and IL-10 in the observation group were significantly lower than those before treatment,which were also significantly lower than those in the control group(P<0.05).The incidence of adverse reactions in the two groups was similar(4.44%vs.6.67%).Conclusion Calcium and Zinc Gluconates Oral Solution in the adjuvant treatment of children patients with mild diarrhea is helpful to enhance the clinical efficacy,it can improve the levels of myocardial enzymes and inflammatory factors.

关 键 词：葡萄糖酸钙锌口服溶液 小儿 轻度腹泻 临床疗效 心肌酶 炎性因子 

分 类 号：R969.4[医药卫生—药理学] R975.3[医药卫生—药学]