胰高血糖素样肽-2的研究进展  

Research Advance of Glucagon-like Peptide-2

作　　者：邴新帅 桑丹 孙海洲[2] 李胜利[2] 金鹿[2] 张春华[2] 张崇志[2] 崔爽青[1] 李萌萌 韩勇军 BINGXinshuai;SANGDan;SUN Haizhou;LIShengli;JINLu;ZHANGChunhua;ZHANGChongzhi;CUIShuangqing;LIMengmeng;HANYongjun(College of Animal Science,Inner Mongolia Agricultural University,Hohhot,Inner Mongolia 010031,China;Institute of Animal Nutrition and Feed,Inner MongoliaAcademy of Agriculture and Animal Husbandry Sciences,Hohhot, Inner Mongolia 010031,China;Ordos Agriculture and Animal Husbandry Bureau,Hohhot,Inner Mongolia 010031,China)

机构地区：[1]内蒙古农业大学动物科学学院,内蒙古呼和浩特010031 [2]内蒙古农牧业科学院动物营养与饲料研究所,内蒙古呼和浩特010031 [3]鄂尔多斯市农牧业局,内蒙古呼和浩特010031

出　　处：《家畜生态学报》2019年第6期7-13,共7页Journal of Domestic Animal Ecology

基　　金：内蒙古农牧业科技创新基金项目;国家现代农业产业技术体系建设专项资金资助(CARS-39-11);内蒙古自治区科技创新引导项目;内蒙古农牧业青年创新基金项目

摘　　要：胰高血糖素样肽-2(glucagon-like peptide-2,GLP-2)是由肠道内分泌L细胞合成分泌的、胰高血糖素原经转录、翻译后加工处理的33个氨基酸多肽。文章介绍了GLP-2的合成、代谢与生理功能,GLP-2在动物肠道内可促进肠道营养吸收、抗炎、促进肠道损伤修复,在肠道外可以通过脑-肠轴调节食物摄取、血压、胰高血糖素的分泌和骨的重吸收;对GLP-2发挥生物活性的可能作用途径cAMP/蛋白激酶途径、PI-3K/Akt途径、激活ERK1和ERK2途径、刺激生长因子的释放等途径进行阐述;并对GLP-2和GLP-2类似物在人的疾病治疗和动物生产中的应用进行概述。Glucagon-like peptide-2(GLP-2)is synthesized and secreted by intestinal endocrine L cells, and is 33 amino acid polypeptides that have been processed by transcription and posttranslational processing of glucagon.This article introduces the synthesis,metabolism and physiological function of GLP-2. GLP-2 can promote intestinal nutrient absorption,anti-inflammatory,and intestinal damage repair in the gut,and regulates food intake,blood pressure,glucagon secretion,and bone reabsorption through the brain-gut axis outside the gut of animals.Possible pathways for GLP-2 bioactivity,the cAMP/protein ki-nasepathway,the PI-3K/Akt pathway,the activation of the ERK1 and ERK2 pathways,and the stimula-tion of the release of growth factors were described.And the use of GLP-2 and GLP-2 analogs in human disease treatment and animal production was outlined.

关 键 词：胰高血糖素样肽-2 胰高血糖素样肽-2受体 肠道健康 

分 类 号：S811.5[农业科学—畜牧学]