肿瘤患者CYP2C8基因多态性与紫杉醇不良反应的相关性研究  

Correlation Study between CYP2C8 Gene Polymorphim and Adverse Reaction of Paclitaxel in Cancer Patients

作　　者：许秋霞[1] 周细萍 叶磊[2] 庄奕筠[1] 陈金成[1] 张吟[1] XU Qiu-xia;ZHOU Xi-ping;YE Lei;ZHUANG Yi-jun;CHEN Jin-cheng;ZHANG Yin(Department of Pharmacy,The Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,China;TCM Department,The Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,China;Department of Pharmacy,Quanzhou Taiwan Investment Zone Hospital,Quanzhou 362700,China)

机构地区：[1]福建医科大学附属第二医院药学部,福建泉州362000 [2]福建医科大学附属第二医院中医科,福建泉州362000 [3]泉州台商投资区医院药剂科,福建泉州362700

出　　处：《中国药学杂志》2019年第12期1007-1011,共5页Chinese Pharmaceutical Journal

基　　金：福建省科技厅社会发展引导性(重点)项目资助(2015Y0055);福建省卫计委青年科研课题项目资助(2015-1-60);泉州市医疗卫生指导性项目资助(2015QZZD13);福建医科大学附属第二医院苗圃基金项目资助(2013MP05)

摘　　要：目的探讨肿瘤患者CYP2C8基因多态性与紫杉醇不良反应的关系。方法选择我院2016年1月~2018年5月接受紫杉醇化疗的肿瘤患者52例作为研究对象,检测其CYP2C8基因型,并观察、收集、记录其不良反应发生情况,分析患者的不良反应发生和基因多态性的相关性。结果本研究共检测了25个基因位点,仅7个基因位点有发生突变,其余18个基因位点均为野生型。本研究发现,在CYP2C8基因多态性中,携带CYP2C8*1B(-271 C>A)野生型基因(CC)患者的血小板减少和疼痛的发生率均高于突变型基因(CA+AA),差异有统计学意义(P<0.05);携带CYP2C8*2/*3(32299 C>T)野生型基因(CC)患者的肝脏毒性发生率低于突变型基因(CT+TT),差异有统计学意义(P<0.05)。结论CYP2C8基因多态性与紫杉醇的不良反应可能具有相关性。OBJECTIVE To investigate the correlation between CYP2C8 gene polymorphisms and the adverse reactions of paclitaxelin in cancer patients.METHODS Fifty-two patients who received paclitaxel chemotherapy from January 2016 to May 2018 were selected as experimental subjects.The CYP2C8 genotypes of the selected patients were tested and the adverse reactions of paclitaxel were observed,collected and recorded to explore the relationship between adverse reactions and genetic polymorphism.RESULTS In this study,25 gene loci were detected,only 7 gene loci had mutation,and the remaining 18 gene loci were all wild-type.In the polymorphism of CYP2C8 gene,the incidence of thrombocytopenia and pain in patients with CYP2C8*1B(-271C>A)wild-type(CC)was significantly higher than that in mutant(CA+AA)(P<0.05).And the incidence of hepatotoxicity in patients with CYP2C8*2/*3(32299C>T)wild-type gene(CC)was significantly lower than that in mutant gene(CT+TT)(P<0.05).CONCLUSION The polymorphism of CYP2C8 gene may be associated with the adverse reaction of paclitaxel.

关 键 词：紫杉醇 基因多态性 CYP2C8 不良反应 

分 类 号：R969.[医药卫生—药理学]