自噬与糖尿病视神经病变  

The autophagy and diabetic optic neuropathy

作　　者：王立 宋鄂 Wang Li;Song E(Lixiang Eye Hospital of Soochow University, Suzhou 215021, China)

机构地区：[1]苏州大学附属理想眼科医院,215021

出　　处：《国际眼科纵览》2019年第3期175-179,共5页International Review of Ophthalmology

摘　　要：自噬是细胞内物质的降解途径之一,介导细胞内蛋白和部分细胞器的降解,对维持神经元内环境稳态具有重要的生理功能。自噬是糖尿病视神经病变(diabetic optic neuropathy,DON)治疗的潜在靶点。高糖可通过调节mTOR信号通路,影响DON发生发展;同时自噬在DON的转归过程中发挥双刃剑作用,其对于DON发挥的作用是保护还是加重损伤尚不明确。体内氧化应激、多元醇等代谢途径对自噬过程进行调控,利用自噬作用对DON进行治疗具有重要意义。Autophagy is an evolutionarily conserved lysosomal degradation pathway that controls cellular bioenergetics and cytoplasmic quality. Hence, an effective autophagic clearance system is essential for maintaining the normal physiological function of nerve cells. The autophagy pathway plays a key role in regulation of autophagy related signaling pathways impact on the development of diabetic optic neuropathy ( DON) . It is verified that many metabolic pathways modulate autophagy by positive and negative regulation and it plays a double-edged role in the progression of DON. To elucidate and take advantage of autophagy to manage neurodegeneration in DON is of great importance.

关 键 词：自噬 糖尿病视神经病变 神经变性疾病 信号通路 

分 类 号：R587.2[医药卫生—内分泌] R774.6[医药卫生—内科学]