贵州省1115户居民家庭结构和乙肝感染家庭聚集性关系研究  

Study on Association of Family Structures with Family Aggregation of Hepatitis B Virus Infection in 1 115 Households in Guizhou Province

作　　者：卜苏洪 黄文湧 汪俊华 蒋芝月 官志忠[3] 杨敬源 BU Suhong;HUANG Wenyong;WANG Junhua;JIANG Zhiyue;GUAN Zhizhong;YANG Jingyuan(School of Public Health,Guizhou Medical University,Guiyang 550025,Guizhou,China;The Key Laboratory of EnvironmentalPollution and Disease Surveillance,Ministry of Education,Guizhou Medical University,Guiyang 550025,Guizhou,China;The Key Laboratory of Medical Molecular Biology,Guizhou Medical University,Guiyang 550025,Guizhou,China;Guizhou Institute of Health Development Research,Guiyang 550025,Guizhou,China)

机构地区：[1]贵州医科大学公共卫生学院,贵州贵阳550025 [2]贵州医科大学环境污染与疾病监控教育部重点实验室,贵州贵阳550025 [3]贵州医科大学分子生物重点实验室,贵州贵阳550025 [4]贵州省卫生发展研究院,贵州贵阳550025

出　　处：《贵州医科大学学报》2019年第6期658-663,共6页Journal of Guizhou Medical University

基　　金：科技部“十二五”国家科技支撑计划(2013BAI05B03)

摘　　要：目的:探讨贵州省少数民族地区家庭结构与乙肝感染家庭聚集性的关系。方法:采用多阶段整群随机抽样的方法,从贵州省少数民族地区抽取1115户家庭1629人进行调查,并采集5mL静脉血,检测乙肝五项指标;采用二分类非条件Logistic回归模型分析,评估不同家庭结构和乙肝感染家庭聚集性关系。结果:3代同堂家庭乙肝感染家庭聚集性率最高(56.8%),隔代家庭HBV感染率最高(57.7%),不同家庭结构乙肝感染家庭聚集性差异有统计学意义(χ2=38.983,P<0.01);Logistic回归分析在调整相关危险因素后结果显示,与传统家庭相比,隔代家庭(OR=2.544,95%CI为1.254~5.160)、3代同堂家庭(OR=3.984,95%CI为2.497~6.357)、一起生活的人有HBsAg阳性(OR=7.379,95%CI为4.741~11.485),是乙肝感染的危险因素(P<0.05);接种过乙肝疫苗(OR=0.448,95%CI为0.207~0.972)、过去一年家庭总收入≥30000元(OR=0.408,95%CI为0.202~0.825)是家庭聚集性的保护因素(P<0.05)。结论:贵州省少数民族地区隔代家庭和3代同堂家庭是乙肝感染家庭聚集性的高危人群。Objective: To explore the association of family structure with family aggregation of hepatitis B Virus (HBV) infection in ethnic minority areas of Guizhou Province. Methods: 1 629 permanent residents were randomly enrolled from 1 315 households in Guizhou province using a multi-stage cluster random sampling method.5 mL venous blood from every individual was collected to detect five HBV serological indexes.These indexes were analyzed using a two-class unconditional logistic regression model to calculate OR (95% CI) and assess the association of family structures with HBV infection. Results: Among four different family structures,the aggregation rate of HBV infection was the highest rate (56.8%) in the families with three generations living together (FTG),and the rate of HBV infection was the highest rate (57.7%) in the families with only grandparents and children (FGC).One factor chi-square test showed there was a statistically significant difference in the aggregation of HBV infection among different family structures (χ2=38.983,P <0.01).After adjusting the relevant risk factors,two classified non conditional Logistic regression analysis showed that FGC( OR=2.544,95%CI was 1.254~5.160),FTG OR=3.984,95%CI was 2.497~6.357)and living with people who have HBsAg positive( OR=7.379,95%CI was 4.741~11.485)were risk factors of family aggregation of HBV infection( P <0.05).Besides,inoculation of HBV vaccine ( OR=0.448,95%CI was 0.207~0.972 ) and family yearly income ≥￥30 000 ( OR=0.408,95%CI :0.202~0.825) are protective factors from HBV infection ( P <0.05). Conclusion: FGC and FTG members are at high-risk for family aggregation of HBV infection in Guizhou ethic minority areas.

关 键 词：家庭结构 肝炎 乙型 家庭聚集性 少数民族地区 影响因素 

分 类 号：R512.62[医药卫生—内科学]