前列腺小体外泄蛋白与EPS常规指标和NIH-CPSI的相关性分析  

Correlation of the prostatic exosomal protein content with conventional indicators of EPS and NIH-CPSI

作　　者：闫泽晨[1] 李凯强 李奕泽 梁威宁 许松 商学军 YAN Ze-chen;LI Kai-qiang;LI Yi-ze;LIANG Wei-ning;XU Song;SHANG Xue-jun(Department of Surgery The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450052,China;Department of Andrology,Nanjing School of Clinical Medicine,Southern Medical University / General Hospital of Eastern Theater Command,Nanjing,Jiangsu 210002,China;Department of Urology,Nanjing School of Clinical Medicine,Southern Medical University / General Hospital of Eastern Theater Command,Nanjing,Jiangsu 210002,China)

机构地区：[1]郑州大学第一附属医院外科医学部,河南郑州450052 [2]南方医科大学南京临床医学院/东部战区总医院男科,江苏南京210002 [3]南方医科大学南京临床医学院/东部战区总医院泌尿外科,江苏南京210002

出　　处：《中华男科学杂志》2019年第6期500-503,共4页National Journal of Andrology

基　　金：2017年度军队计生专项研究任务计划(17JS013);江苏省社会发展面上项目(BE2017724)~~

摘　　要：目的:研究慢性前列腺炎(CP)患者尿液中的前列腺小体外泄蛋白(PSEP)的含量与前列腺按摩液(EPS)中的白细胞(WBC)、卵磷脂小体(SPL)及NIH-CPSI评分之间的关系。方法:收集2017年11月至2018年8月前来东部战区总医院男科门诊就诊的367例CP患者的中段尿进行PSEP含量检测,显微镜下观察EPS中的WBC和SPL计数,指导患者独立填写NIH-CPSI量表,统计分析CP患者尿液中的PSEP含量与EPS中的WBC、SPL计数及NIH-CPSI评分之间的相关性。结果:CP患者尿液中的PSEP含量随EPS中的WBC数量增加而增加,二者具有显著相关性(r=0.19,P=0.047),与EPS中的SPL计数无明显相关性(r=0.02,P=0.48),与NIH-CPSI总评分显著相关(r=0.31,P=0.02)。结论:PSEP对临床诊断CP和评估CP的炎症程度具有一定意义。Objective: To study the relationship of the content of prostatic exosomal protein(PSEP) in the urine with the counts of WBCs and small particles of lecithin(SPL) in the EPS and NIH-CPSI in patients with chronic prostatitis. Methods: We collected mid-stream urine samples from 367 chronic prostatitis patients in the Department of Andrology of the General Hospital of Eastern Theater Command from November 2017 to August 2018. We measured the content of PSEP in the urine, counted WBCs and SPLs in the EPS of the patients, obtained their NIH-CPSI scores, and analyzed the correlation of the PSEP level with the WBC and SPL counts and NIH-CPSI scores of the patients. Results: The PSEP level in the urine was elevated with the increase of the WBC count in the EPS of the patients(r = 0.19, P = 0.047) but not significantly correlated with the SPL count in the EPS(r = 0.02, P = 0.48). A significant correlation was observed between the PSEP level and the NIH-CPSI scores of the patients(r = 0.31, P = 0.02). Conclusion: The PSEP content in the urine can be used as an indicator in the clinical diagnosis and assessment of the inflammation degree of chronic prostatitis.

关 键 词：慢性前列腺炎 前列腺小体外泄蛋白 卵磷脂小体 尿液 前列腺按摩液 美国国立卫生研究院慢性前列腺炎症状指数 

分 类 号：R697.33[医药卫生—泌尿科学]