沙美特罗替卡松对慢性阻塞性肺疾病急性加重期患者炎症因子和肺功能的影响  

Effect of salmeterol/roticasone on the inflammatory factors and lung function in patients with acute exacerbation of chronic obstructive pulmonary disease

作　　者：王美玲[1] 秦晓鸥[1] 王春荣[1] 陈云 于会云 Wang Meiling;Qin Xiaoou;Wang Chunrong;Chen Yun;Yu Huiyun(Department of Internal Medicine,Zhuozhou City Hospital,Zhuozhou 072750,China)

机构地区：[1]涿州市医院内科,072750

出　　处：《国际呼吸杂志》2019年第12期911-915,共5页International Journal of Respiration

基　　金：保定市科技计划项目任务书(18ZF160).

摘　　要：目的探讨沙美特罗替卡松(舒利迭)对慢性阻塞性肺疾病急性加重期(AECOPD)患者血清炎症因子和肺功能指标的影响。方法选取2016年3月至2018年3月涿州市医院AECOPD患者100例,依据随机数字表法分为常规治疗组(常疗组)和舒利迭治疗组(舒疗组),每组50例.常疗组给予常规治疗,舒疗组在此基础上给予舒利迭治疗,比较两组血清炎症因子白细胞介素6 (IL-6)、可溶性E-选择素(sE-SLT)、可溶性细胞间黏附分子-1(sICAM-1)、第1秒用力呼气容积(FEV1、FEV1占预计值百分比(FEV1%pred)、FVC、COPD评估测试评分(CAT)、圣乔治呼吸问卷(SGRQ)、不良反应的差异。结果常规治疗组和舒疗组治疗后IL-6、sE-SLT、sICAM-1、CAT、SGRQ明显低于治疗前,舒疗组治疗后IL-6、sE-SLT、sICAM-1、CAT、SGRQ明显低于常疗组,常疗组和舒疗组治疗后FEV1、FEV1%pred. FVC明显高于治疗前,舒疗组治疗后FEV1、FEV1%pred、FVC明显高于常疗组,差异有统计学意义(P<0.05);常疗组和舒疗组总不良反应发生率(心跳加快、头晕、恶心、呕吐等)比较,差异无统计学意义(P>0.05)。结论舒利迭可有效改善AECOPD患者炎症状态和肺功能,有利于提高患者的病情控制效果及生活质量.且安全性好。Objective To discuss the effect of salmeterol/roticasone ( seretide ) on the inflammatory factors and lung function in patients with acute exacerbation of chronic obstructive pulmonary disease ( AECOPD) .Methods 100 patients with AECOPD were selected from March 2016 to March 2018 in Zhuozhou City Hospital ,according to the random number table method ,they were divided into routine therapy group and relaxation therapy group ,50 cases in each group .The routine therapy group was given routine treatment ,and the relaxation therapy group was given seretide treatment on this basis .The inflammatory factors IL-6 ,soluble E-selectin ( sE-SLT ) , soluble intercellular adhesion molecule-1 ( sICAM-1 ) and pulmonary function 1 s total forced expiratory volume ( FEV1 ) ,the estimated percentage FEV1 ( FEV1% pred) ,forced vital capacity (FVC) ,condition control [COPD assessment test score (CAT)] ,quality of life [St George respiratory disease questionnaire ( SGRQ ) ] ,adverse reactions were compared between the two groups .Results After treatment ,IL-6 ,sE-SLT ,sICAM-1 ,CAT ,SGRQ in the routine therapy group and the relaxation therapy group were significantly lower than those before treatment .After treatment ,IL-6 ,sE-SLT ,sICAM-1 ,CAT ,SGRQ in the relaxation therapy group were significantly lower than those in routine therapy group ,FEV1 ,FEV1% pred and FVC in routine therapy group and relaxation therapy group were significantly higher than those before treatment ,FEV 1 ,FEV1%pred and FVC in the relaxation therapy group were significantly higher than those in routine therapy group ( P < 0 .05) .The incidence of the total adverse reactions ( accelerated heartbeat ,dizziness , nausea ,vomiting ) between routine therapy group and relaxation therapy group ,there were no statistical difference ( P > 0 .05) .Conclusions Seretide can effectively improve the inflammation and lung function of patients with AECOPD ,and it is conducive to improving the patient's condition control effect and quality of life ,it has the good safety .

关 键 词：舒利迭:肺疾病.慢性阻塞性.急性加重期 炎症 肺功能 

分 类 号：R563.9[医药卫生—呼吸系统]