微生物组学在哮喘中的研究进展  

Research progress of microbiology in asthma

作　　者：旷健 黄榕[1] 刘沉涛[1] Kuang Jian;Huang Rong;Liu Chentao(Department of Paediatrics,Xiangya Hospital of Central South University,Changsha 410008,China)

机构地区：[1]中南大学湘雅医院儿科,长沙410008

出　　处：《国际呼吸杂志》2019年第12期932-936,共5页International Journal of Respiration

摘　　要：微生物组学指寄居在人体内的微生物种类及其基因和基因组的总和.生命早期形成的微生物群在宿主的成长和免疫系统发育中起重要作用,延迟或被改变的这些微生物群将增加过敏和哮喘发病的风险.本文将对微生物组学在肺部免疫调节中的可能机制,以及肠道和呼吸道微生物群改变在哮喘发病中的作用作一综述.Microbiology refers to the sum of microorganism species, genes and genomes that reside in the human body. Microbial communities formed early in life play an important role in host growth and immune system development.and delayed or altered microbial communities may in crease the risk of allergies and asthma.This article reviews the possible mechanism of microorganism group in lung immunomodulation,and the role of intestinal and respiratory microbial comm unity changes in the pathogenesis of asthma.

关 键 词：微生物组 哮喘 支气管 研究进展 

分 类 号：R562.25[医药卫生—呼吸系统]