慢性乙型肝炎及乙型肝炎后肝硬化患者血浆血管紧张素Ⅱ和醛固酮的变化  

Changes of angiotensin Ⅱ and Aldosterone in patients with chronic hepatitis B and hepatitis B cirrhosis

作　　者：沈兰超[1] 丁蔚茅 张睿[1] 张梅芹 华小丽 姜红梅 SHEN Lanchao;DING Weimao;ZHANG Rui(Department of Liver Diseases,Huai’an 223000, CHINA)

机构地区：[1]淮安市第四人民医院肝病科

出　　处：《江苏医药》2019年第6期561-564,共4页Jiangsu Medical Journal

摘　　要：目的探讨慢性乙型肝炎及乙型肝炎后肝硬化患者血浆血管紧张素Ⅱ(AngⅡ)和醛固酮(ALD)的变化。方法选取慢性乙型肝炎患者30例和乙型肝炎后肝硬化患者30例,口服恩替卡韦0.5 mg治疗12周,检测治疗前及治疗12周血浆AngⅡ和ALD水平,分析其与ALT、白蛋白(Alb)、TBil、HBV-DNA及Child-Pugh评分的相关性。结果与治疗前比较,治疗12周后慢性乙型肝炎患者ALT、HBV-DNA、AngⅡ和ALD降低,Alb升高(P<0.05)。治疗前,慢性乙型肝炎患者血浆AngⅡ水平与ALT呈正相关(P<0.05),与Alb呈负相关(P<0.05)。与治疗前比较,治疗12周后乙型肝炎后肝硬化患者TBil、ALT、HBV-DNA、Child-Pugh评分和ALD降低,Alb升高(P<0.05)。治疗前,乙型肝炎后肝硬化患者血浆ALD水平与TBil和Child-Pugh评分呈正相关(P<0.05),与Alb呈负相关(P<0.05)。结论经恩替卡韦治疗后,慢性乙型肝炎和乙型肝炎后肝硬化患者血浆AngⅡ和ALD水平有不同程度的下降,可能与患者的肝功能有关。Objective To investigate the changes of angiotensin Ⅱ(AngⅡ) and Aldosterone(ALD) in the patients with chronic hepatitis B and hepatitis B cirrhosis.Methods Thirty patients with chronic hepatitis B and 30 patients with hepatitis B cirrhosis were treated with entecavir 0.5 mg for 12 months.Serum levels of AngⅡ and ALD were detected before and after treatment.The relationship of AngⅡ and ALD with ALT,albumin,TBil,HBV-DNA and Child-Pugh score was analyzed.Results Compared to before,the levels of ALT,HBV-DNA,AngⅡ and ALD were lower and albumin was higher 12 weeks after treatment in the patients with chronic hepatitis B(P<0.05).The level of AngⅡ was positively correlated to that of ALT and negatively correlated to that of albumin in the patients with chronic hepatitis B before treatment(P<0.05).Compared to before,the levels of TBil,ALT,HBV-DNA,Child-Pugh score and ALD were lower and albumin was higher in the patients with hepatitis B cirrhosis 12 weeks after treatment(P<0.05).The level of ALD was positively correlated to that of TBil and Child-Pugh score and negatively correlated to that of albumin in the patients with hepatitis B cirrhosis(P<0.05).Conclusion Serum levels of AngⅡ and ALD in the patients with chronic hepatitis B and hepatitis B cirrhosis were decreased at different degrees,which may be related to the liver function.

关 键 词：慢性乙型肝炎 乙型肝炎后肝硬化 血管紧张素Ⅱ 醛固酮 

分 类 号：R512[医药卫生—内科学]