磁性纳米颗粒标记间充质干细胞及对其功能的调控  

Magnetic Nanoparticles for Labelling and Functional Regulation of Mesenchymal Stem Cells

作　　者：马思雨 王鹏 杨玉志[2] 孙剑飞[1,4] 顾宁 MA Siyu;WANG Peng;YANG Yuzhi;SUN Jianfei;GU Ning(Jiangsu Key Laboratory for Biomaterials and Devices,State Key Laboratory of Bioeletronics,School of Biological Sciences & Medical Engineering,Southeast University,Nanjing 210096,China;Clinical Medical Engineering Office,Nanjing Drum Tower Hospital of Nanjing University Medical School,Nanjing 210008,China;Department of Sports Medicine and Adult Reconstructive Surgery,Nanjing Drum Tower Hospital of Nanjing University Medical School,Nanjing 210008,China;Collaborative Innovation Center of Suzhou Nano-Science and Technology,Suzhou 215123,China)

机构地区：[1]东南大学生物科学与医学工程学院江苏省生物材料与器件重点实验室生物电子学国家重点实验室,江苏南京210096 [2]南京大学医学院附属鼓楼医院临床医学工程处,江苏南京210008 [3]南京大学医学院附属鼓楼医院运动医学与成人重建外科,江苏南京210008 [4]苏州纳米科技协同创新中心,江苏苏州215123

出　　处：《中国材料进展》2019年第6期559-566,共8页Materials China

基　　金：国家重点研发计划项目(2017YFA0104301)

摘　　要：干细胞治疗是目前组织修复领域中最有潜力的治疗方法,但由于缺乏有效的干细胞示踪技术等原因,目前的多数研究都还停留在实验阶段。需要利用干细胞体内示踪技术对移植到体内后干细胞的分布、活性、分化、凋亡情况进行检测。因此,干细胞示踪技术的发展对解决上述问题起到了至关重要的作用。目前,磁性纳米颗粒标记干细胞后,利用磁共振成像技术(magnetic resonance imaging,MRI)有望实现体外无创、实时、安全、有效的长期示踪观察。对间充质干细胞的组织修复原理、磁性纳米颗粒参与协助间充质干细胞的组织修复以及磁性纳米颗粒标记干细胞的技术进行了系统综述。Stem cell therapy is the most promising treatment in the field of tissue repair. However,vast majority of current investigations still remain in the stage of laboratory. It is of great significance to detect the distribution,activity,differentiation and apoptosis of stem cells after transplantation by in-vivo tracing technique. Therefore,the development of the techniques for tracing stem cells has played a crucial role in solving these problems. Nowadays,magnetic resonance imaging (MRI) has been used to explore long-term in-vitro tracing of magnetic nanoparticles labeled stem cells. Furthermore,it is noninvasive,real-time,safe and effective. The principle of mesenchymal stem cells (MSCs) for tissue repair was systematically summarized. Also,the labeling and assistance effect of magnetic nanoparticles on MSCs for tissue repair were reviewed.

关 键 词：磁性纳米颗粒 间充质干细胞 组织修复 标记 

分 类 号：Q819[生物学—生物工程]