自体脂肪及脂肪干细胞填充治疗面部老化的疗效  

Clinical efficacy of autologous fat plus adipose Stem cells filling in treatment of facial aging

作　　者：赵伟[1] 廖农[1] 王君[1] 林维欣[1] Wei Zhao;Nong Liao;Jun Wang;Wei-xin Lin(Department of Plastic surgery,the Third Affiliated Hospital of Guangzhou Medical University,Guangzhou,Guangdong 510150,China)

机构地区：[1]广州医科大学附属第三医院整形外科

出　　处：《中国现代医学杂志》2019年第13期94-97,共4页China Journal of Modern Medicine

摘　　要：目的观察改良方法制备含有较多脂肪干细胞的自体脂肪进行移植填充治疗面部老化的临床效果。方法选取在广州医科大学附属第三医院整形外科进行抗面部老化治疗的患者96例,根据脂肪提取与移植方法不同分为对照组和观察组。对照组患者(60例)接受传统自体颗粒脂肪移植治疗;观察组患者(36例)接受改良的脂肪移植治疗术。术后随访12个月,观察两组移植脂肪成活率、患者满意度、并发症与后遗症。结果移植术后6个月,观察组脂肪成活率(71.04±5.42)%高于对照组的(59.78±7.26)%(P<0.05);移植术后12个月,观察组患者总满意率(91.67%)高于对照组(81.67%)(P<0.05);移植术后1年内,对照组患者出现硬结6例,纤维囊肿2例,观察组出现硬结1例,两组患者均未出现其他并发症与后遗症。结论改良的自体脂肪移植术提高了移植脂肪的成活率和患者满意度。Objective To observe the clinical efficacy of autologous fat plus adipose derived stem cells filling in the treatment of facial aging.Methods 96 cases of facial aging admitted in our hospital were selected and divided into control group and observation group.Patients in the control group(n=60)received conventional autologous fat granule transplantation.Patients in the observation group(n=36)received modified fat transplantation treatment which contains more adipose stem cells.After 12 months of follow-up,the survival rate,patient satisfaction,complications and sequelae of the two groups were observed.Results 6 months after transplantation,survival rate in observation group was higher than that of the control group[(71.04±5.42)%vs(59.78±7.26)%,P<0.05].12 months after transplantation,total satisfaction rate in observation group was higher than that of the control group(91.67%vs 81.67%,P<0.05).6 cases of induration and 2 cases of fibrous cyst in the control group and 1 case of induration in the observation group were reported within one year of follow-up.There were no other complications in two groups.conclusion Improved autologous fat transplantation enhances the survival rate and patient satisfaction of transplanted fat.

关 键 词：脂肪干细胞 血管再生 自体脂肪 脂肪移植 面部老化 面部年轻化 碱性成纤维细胞生长因子 移植脂肪成活率 

分 类 号：R622.9[医药卫生—整形外科]