不同程度老年2型糖尿病周围神经病变患者胃肠动力障碍相关分析  

Correlation analysis of gastrointestinal motility disorder in elderly patients with type 2 diabetic peripheral neuropathy

作　　者：文茜 许辉 叶茂 于静 Wen Xi;Xu Hui;Ye Mao(Department of Endocrinology,The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture,Enshi 445000,China)

机构地区：[1]恩施土家族苗族自治州中心医院内分泌内科

出　　处：《中华保健医学杂志》2019年第3期195-197,共3页Chinese Journal of Health Care and Medicine

基　　金：湖北省自然科学基金计划项目(2011CDC146)

摘　　要：目的探讨不同程度老年2型糖尿病(T2DM)周围神经病变(DPN)患者胃肠动力障碍相关分析。方法选取2013年1月~2018年1月在恩施土家族苗族自治州中心医院接受治疗的T2DM患者98例,依据周围神经病变相关辅助检查和周围神经相关临床症状分为无病变组(35例)、轻度病变组(30例)和中重度病变组(33例),记录患者临床资料,包括年龄、性别、是否存在周围神经病变症状、是否存在消化道症状等,患者入院后次日早晨检测患者低密度脂蛋白(LDL)、空腹血糖(FBG)、三酰甘油(TG)及糖化血红蛋白(HbA1c)含量状况,使用XDJ-S8B型胃肠动力检测仪行胃肠电图检测,包含波形平均幅值(AP)、波形主频(DF)、波形反应面积(RA)和餐后与餐前功率比值。结果3组患者血清LDL、FBG、TG及HbA1c含量对比,差异无统计学意义(P>0.05);无病变组、轻度病变组患者餐后RA、餐后波幅高于中重度病变组,无病变组餐后/餐前功率比值高于轻度、中重度病变组,差异有统计学意义(P<0.05);患者体质量指数(BMI)和餐前RA、餐前波幅呈负相关(P<0.05),BMI、HbA1c及FBG和餐后与餐前的功率比呈正相关(P<0.05),病程和年龄与餐后与餐前的功率比呈负相关关系(P<0.05)。结论2型糖尿病DPN老年患者的胃电图在前期就会发生异常,并且伴随患者病情加重其胃电图异常会更显著。Objective To investigate the correlation of gastrointestinal motility disorders in patients with different degrees of senile type 2 diabetes (T2DM) peripheral neuropathy (DPN). Methods Ninety-eight elderly patients with type 2 DM treated in our hospital between January 2013 and January 2018 were selected. They were divided into non-lesion group(35 cases) and mild disease group(30 cases)and moderate-to-severe lesions(33 cases)according to the auxiliary test and clinical symptoms. Blood low-density lipoprotein(LDL),fasting plasma glucose(FBG),triglyceride(TG),and glycosylated hemoglobin(HbA1c) mean amplitude(AP),waveforms frequency(DF),waveform response area,and postprandial to preprandial power ratio were examined. Results There was no significant difference in serum LDL,FBG,TG and HbA1c levels in the three groups(P > 0.05). Post-prandial RA and postprandial wave amplitudes were higher in the non-lesioned and mildly affected patients than in the moderately-severe patients. The postprandial/preprandial power ratio in the diseased group was higher than that in the mild to moderately severe disease group(P < 0.05);the BMI was negatively correlated with the preprandial RA and the preprandial amplitude(P < 0.05). The power rafio after meal and pre-meal was positively correlated(P < 0.05),and the relationship between disease duration and age was negatively correlated with post-meal and pre-meal power ratio(P < 0.05). Conclusion The elderly patients with diabetic DPN may have abnormal electrogastrograms in the early stage,and the abnormal electrogastrogram may be more serious with the exacerbation of the patient's condition.

关 键 词：糖尿病周围神经病变 糖尿病胃动力障碍 胃电图 

分 类 号：R587.2[医药卫生—内分泌]