阿托伐他汀钙对改善慢性硬膜下血肿出血量及神经功能的价值  

The Value of Atorvastatin Calcium in Improving the Amount of Hemorrhage and Neurological Function in Chronic Subdural Hematoma

作　　者：孙广升 王燕[2] SUN Guang-sheng;WANG Yan(Department of Neurosurgery,the First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou,Inner Mongolia,014000 China;Department of Neurosurgery,Baotou Steel Hospital,Baotou,Inner Mongolia,014010 China)

机构地区：[1]内蒙古科技大学包头医学院第一附属医院神经外科,内蒙古包头014000 [2]内蒙古包钢医院神经外科,内蒙古包头014010

出　　处：《中外医疗》2019年第14期23-25,共3页China & Foreign Medical Treatment

基　　金：国家自然科学基金(No.81660214,51572144);内蒙古科技厅科技计划项目(201702101);内蒙古卫生厅(201701097);包头市医药卫生基金(2017S2001-7-1);包头医学院科学研究基金(BYJJ-YF-2018004)

摘　　要：目的探讨阿托伐他汀钙对改善慢性硬膜下血肿出血量及神经功能的价值。方法便利收集2017年3月—2018年4月该院100例慢性硬膜下血肿的患者,两组患者入院后给予营养神经、改善微循环、对症治疗。研究组在上述治疗上口服阿托伐他汀钙片。对比两组治疗前后慢性硬膜下血肿出血量;两组治疗前后神经功能;两组治疗前后体内炎症因子水平。结果研究组和对照组治疗前慢性硬膜下血肿出血量分别为[(74.25±16.71)mL、(75.16±17.44)mL],差异无统计学意义(t=0.355,P>0.05);研究组和对照组治疗后慢性硬膜下血肿出血量分别为[(23.26±7.23)mL、(53.15±8.96)mL],差异有统计学意义(t=6.332,P<0.05);研究组和对照组治疗前中国卒中量表分别为[(22.36±3.27)分、(22.09±4.02)分]差异无统计学意义(t=0.147,P>0.05);研究组和对照组治疗后中国卒中量表分别为[(12.85±1.98)分、(14.28±2.05)分]差异有统计学意义(t=5.287,P<0.05)。研究组手术后1d及手术后3dTNF-β及IL-4炎症因子指标均低于对照组,两组分别为[(39.62±5.14)ng/L、(56.24±15.34)ng/L、(5.42±1.18)ng/L、(12.16±1.87)ng/L]、[(59.14±5.22)ng/L、(7.96±3.37)ng/L、(65.97±16.02)ng/L、(23.64±2.26)ng/L],差异有统计学意义(P<0.05)。结论阿托伐他汀钙能够明显减少慢性硬膜下血肿患者的出血量,同时对提高神经功能有重要价值。Objective To investigate the value of atorvastatin calcium in improving the amount of hemorrhage and neurological function in chronic subdural hematoma. Methods 100 patients with chronic subdural hematoma in our hospital from March 2017 to April 2018 were convenient selected and enrolled. The patients in the two groups were given nutritional nerves, improved microcirculation and symptomatic treatment after admission. The study group took oral atorvastatin calcium tablets on the above treatment. The amount of chronic subdural hematoma bleeding before and after treatment was compared between the two groups;as well as the neurological function before and after treatment;the levels of inflammatory factors in the two groups before and after treatment. Results The blood loss of chronic subdural hematoma in the study group and the control group was [(74.25±16.71)mL,(75.16±17.44)mL], the difference was not statistically significant (t=0.355, P>0.05). The study group and the control group after the treatment of the amount of post-chronic subdural hematoma was [(23.26±7.23)mL,(53.15±8.96)mL], the difference was statistically significant (t=6.332, P<0.05). The Chinese stroke scales of the study group and the control group were[(22.36±3.27)points, 22.09±4.02)points]. The difference was not statistically significant (t=0.147, P>0.05). The Chinese stroke scales of the study group and the control group were[(12.85±1.98)points,(14.28±2.05)points]. The difference was statistically significant (t=5.287, P<0.05). The TNF-β and IL-4 inflammatory factors were lower in the study group than in the control group 1 day after surgery and 3 days after surgery. The two groups were [(39.62±5.14)ng/L,(56.24±15.34)ng/L,(5.42±1.18)ng/L,(12.16±1.87)ng/L],[(59.14±5.22)ng/L,(7.96±3.37)ng/L,(65.97±16.02)ng/L,(23.64±2.26)ng/L], the difference was statistically significant (P<0.05). Conclusion Atorvastatin calcium can significantly reduce the amount of bleeding in patients with chronic subdural hematoma, and it is of great value in i

关 键 词：阿托伐他汀钙 慢性硬膜下血肿 出血量 神经功能 

分 类 号：R651[医药卫生—外科学]