冠心病患者血清RBP4、hs-CRP、IL-6水平检测的临床意义  

Clinical significance of detection of serum RBP4,hs-CRP and IL-6 levels in patients with coronary heart disease

作　　者：黄乐[1] 林德智[1] 倪卫[1] 段丙军[1] Huang Le;Lin Dezhi;Ni Wei;Duan Bingjun(Department of Cardiology, the First People's Hospital of Neijiang, Neijiang 641000, China)

机构地区：[1]内江市第一人民医院心内科

出　　处：《中国循证心血管医学杂志》2019年第6期691-693,697,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：四川省卫生和计划生育委员会科研课题(16PJ0202)

摘　　要：目的探讨冠心病(CHD)患者血清视黄醇结合蛋白4(RBP4)、高敏C反应蛋白(hsCRP)、白细胞介素-6(IL-6)水平检测的临床意义。方法选择内江市第一人民医院心内科于2017年1月至2018年1月就诊的CHD患者142例作为研究对象,另选取同期体检健康人50例作为对照组,比较两组患者血清hs-CRP、IL-6和RBP4水平,并分析CHD患者血清hs-CRP、IL-6和RBP4与冠心病病变程度的相关性。结果心肌梗死组、不稳定型心绞痛组、稳定型心绞痛组血清hs-CRP、IL-6、BRP4水平显著高于对照组,心肌梗死组、不稳定型心绞痛组血清hs-CRP、IL-6、BRP4水平显著高于稳定型心绞痛组(P<0.05)。随病变支数及病变程度增加冠心病患者血清hs-CRP、IL-6、BRP4水平逐渐升高,不同病变支数及病变程度冠心病患者血清hs-CRP、IL-6、BRP4水平有统计学差异(P<0.05)。Pearson相关性分析显示,CHD组患者的血清RBP4与hs-CRP、IL-6表达呈正相关(r=0.476,0.584,P<0.05);血清RBP4、hs-CRP、IL-6与Gensini积分呈正相关(r=0.672,0.574,0.465,P<0.05)。结论血清RBP4、hs-CRP、IL-6水平升高可以反应CHD患者冠状动脉病变范围及狭窄程度。Objective To investigate the clinical significance of detecting serum retinol binding protein 4(RBP4),high-sensitivity C-reactive protein(hs-CRP) and interleukin-6(IL-6) in patients with coronary heart disease(CHD).Methods A total of 142 patients with CHD in the First People’s Hospital of Neijiang from January 2017 to January2018 were enrolled in the study. Another 50 healthy subjects were selected as the control group. The serum levels of hs-CRP, IL-6 and RBP4 were compared. The correlation between serum hs-CRP, IL-6 and RBP4 in patients with CHD and coronary heart disease was analyzed. Results The serum level of hs-CRP, IL-6 and BRP4 in myocardial infarction group, unstable angina pectoris group and stable angina pectoris group was significantly higher than that in control group. The serum level of hs-CRP, IL-6 and BRP4 in the myocardial infarction group and the unstable angina pectoris group was significantly higher than that in the stable angina pectoris group(P<0.05). The serum level of hsCRP, IL-6 and BRP4 in patients with coronary heart disease increased gradually with the increase of the number of lesions and the degree of lesions, there was significant difference in the serum level of hs-CRP, IL-6 and BRP4 in patients with coronary heart disease with different lesions and the degree of lesions(P<0.05). Pearson correlation analysis showed that serum RBP4 was positively correlated with the expression of hs-CRP and IL-6 in CHD patients(r=0.476, 0.584, P<0.05), and the serum RBP4, hs-CRP, IL-6 was positively correlated with the Gensini score(r=0.672,0.574, 0.465, P<0.05). Conclusion The elevated levels of RBP4, hs-CRP and IL-6 can reflect the extent and stenosis of coronary artery disease in CHD patients.

关 键 词：血清视黄醇结合蛋白4 冠心病 动脉粥样硬化 

分 类 号：R541.4[医药卫生—心血管疾病]