强化降压治疗对高血压患者早期形态学及半乳糖凝集素3的影响  

Effect of intensive antihypertensive therapy on early morphology and galectin-3 in patients with hypertension

作　　者：赵先锋 徐予 高传玉 Zhao Xianfeng;Xu Yu;Gao Chuanyu(Fuwai Central China Cardiovascular hospital, Zhengzhou University People's Hospital.Zhengzhou 450003, China)

机构地区：[1]阜外华中心血管病医院郑州大学人民医院

出　　处：《中国循证心血管医学杂志》2019年第6期725-728,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的评价强化降压治疗对高血压合并左房容积指数(LAVI)扩大患者心脏形态学及半乳糖凝集素-3在血清表达水平的影响。方法选取2015年1月至2016年12月于河南省人民医院心内科收治的原发性高血压并左房容积指数扩大且完成随访住院患者600例,年龄≥18岁。收集入选者相关基础资料、实验室检查结果、应用酶联免疫吸附试验法检测两组药物治疗前后血清半乳糖凝集-3的表达水平,采用超声心动图检测两组患者治疗前后的左房容积,计算容积指数。随访时间截止时间2017年12月,探索强化降压治疗对LAVI及半乳糖凝集素-3的影响,相关分析采用Pearson分析法。结果最终600例受试者完成随访,强化治疗组300例,标准对照组300例,随访15.4±3.2个月,两组间临床基本资料无统计学差异。随访结束,强化组与对照组相比,降压药物种类增多,差异有统计学意义(P<0.05),半乳糖凝集素-3、NT-proBNP下降,LAVI缩小,差异有统计学意义(P<0.05),同时依从性有所下降,差异无达到统计学意义(P>0.05)。全因死亡对照组3例,强化组2例,在观察期间内死亡率有所下降(χ^2=3.68),差异无统计学意义(P>0.05),各种原因再住院率下降,差异有统计学意义(P<0.05),不良反应有所增加,差异无统计学意义(P>0.05)。结论强化降压治疗能改善高血压患者左房容积指数,降低血清半乳糖凝集素-3及NT-proBNP水平,降低再住院率,对预防高血压早期并发症具有一定作用。Objective To evaluate the effect of intensive antihypertensive therapy on cardiac morphology and galectin-3 expression in serum in patients with hypertension complicated with left atrial volume index(LAVI). Methods A total of 600 patients with primary hypertension who underwent cardiovascular surgery in the Department of Cardiology,Henan Provincial People’s Hospital from 2015-01 to 2016-12, and completed follow-up were enrolled, aged ≥18 years.The relevant basic data of the selected persons, laboratory test results, and enzyme-linked immunosorbent assay were used to detect the expression levels of serum galactose agglutination-3 before and after treatment. The left atrial volume of the two groups before and after treatment was detected by echocardiography. Calculate the volume index. The followup time was December 2017, and the effect of intensive antihypertensive therapy on LAVI and galectin-3 was explored.The correlation analysis was performed by Pearson analysis. Results A total of 600 subjects completed the follow-up.There were 300 patients in the intensive treatment group and 300 patients in the standard control group. The follow-up was 15.4±3.2 months. There was no statistical difference between the two groups. At the end of follow-up, the number of antihypertensive drugs increased in the intensive group compared with the control group, the difference was statistically significant(P<0.05), galectin-3, NT-proBNP decreased, LAVI decreased, and the difference was statistically significant(P<0.05), while compliance decreased, the difference was not statistically significant(P>0.05). There were 3 cases of all-cause death control group and 2 cases of intensive group. The mortality rate decreased during the observation period(χ^2=3.68), and the difference was not statistically significant(P>0.05). The rate of rehospitalization decreased for various reasons, and the difference was statistically significant(P<0.05). Adverse reactions increased, and the difference was not statistically significant(P>0.05). Conc

关 键 词：高血压 强化 左房容积指数 半乳糖凝集素3 

分 类 号：R544.1[医药卫生—心血管疾病]