衣原体致病机制的研究策略及挑战  

Challenges and research strategies for the pathogenesis of Chlamydia

作　　者：刘娜 周洲[1] LIU Na;ZHOU Zhou(Institute of pathogenic microorganism of University of South China Hengyang 421000,China)

机构地区：[1]南华大学病原生物学研究所

出　　处：《中国人兽共患病学报》2019年第6期552-557,562,共7页Chinese Journal of Zoonoses

基　　金：国家自然科学基金项目资助(No.31570179)~~

摘　　要：衣原体是一类可以引起人和动物多种疾病的原核细胞型微生物.衣原体致病机制复杂,主要包括对宿主细胞产生的直接致病作用以及感染介导的免疫病理损伤,但现有资料并不能充分解释其致病过程.分子生物学技术的发展,为衣原体致病机制的研究创造便利条件.本文立足于衣原体致病机制,从致病物质、致病机制研究策略以及生物学意义等方面,对衣原体研究的发展现状、面临挑战及未来的工作方向进行概述.Chlamydia is a kind of prokaryotic microorganism which may cause various diseases in human and animals.The pathogenesis of Chlamydia is complex,mainly due to its direct pathogenic effect and the infection-induced immunopathological damage on host cells,but the existing evidences cannot fully explain the processe.Nowadays,the development in techniques of molecular biology offer convenience to research of chlamydial pathogenesis.This paper summarized chlamydial current situation,challenges and the directions in the future work based on its pathogenisis,from the aspects which include pathogenic substances,pathogenesis research strategies and biological significance.

关 键 词：衣原体 蛋白质组学 基因组学 转化 蛋白相互作用 

分 类 号：R374[医药卫生—病原生物学]