丹参酮ⅡA应用于老年充血性心衰的疗效观察  

Protective effect of tanshinone ⅡA on cardiac function and BNP and NO levels in elderly patients with congestive heart failure

作　　者：李毓娟 朱洪斌 赵小瑞 周秀 LI Yujuan;ZHU Hongwu;ZHAO Xiaorui;ZHOU Xiu(Chongqing Kaizhou District people’s hospital, Chongqing 405400, China)

机构地区：[1]重庆市开州区人民医院

出　　处：《中国老年保健医学》2019年第3期56-59,共4页Chinese Journal of Geriatric Care

摘　　要：目的探讨丹参酮ⅡA应用于老年充血性心衰患者对心功能保护及(N末端脑钠素原)BNP、一氧化氮(NO)水平影响。方法 选取我院2015年7月至2016年8月接诊的老年充血性心衰患者80例作为研究对象,按随机法将其分为观察一组(n=40)和观察二组(n=40),观察一组使用常规治疗+丹参酮ⅡA进行治疗,观察组二组进行常规治疗,另外在相同期间选取健康体检者30例作为对照组,采用纽约心脏病协会(NYHA)分级标准对心衰患者进行心功能分级,分析心衰患者和健康体检者的心功能指标、BNP和NO等指标水平情况。结果 两组治疗后NO、BNP水平明显降低,LVEF水平明显上升,并且观察一组NO、BNP水平更低,LVEF水平更高(P<0.05);两组治疗后vWF水平明显降低,6-keto-PGF1a水平明显上升,并且观察一组vWF水平更低,6-keto-PGF1a水平更高(P<0.05);心衰患者NO、BNP水平明显高于对照组,LVEF水平明显低于对照组,患者的心功能分级越高,指标水平变化越明显(P<0.05);心衰患者vWF水平明显高于对照组,6-keto-PGF水平明显低于对照组,患者的心功能分级越高,指标水平变化越明显(P<0.05);观察一组和观察组二组总有效率分别为92.5%和70%,观察一组效率明显更高(P<0.05)。结论 vWF、6-keto-PGF1a以及血管内皮细胞功能与患者心衰严重程度相关,临床治疗老年充血性心衰患者,使用丹参酮ⅡA能够有效改善患者的心功能和血管内皮细胞功能,临床价值较高,值得推广应用。Objective To investigate the effect of tanshinone ⅡA on the protection of cardiac function and the level of BNP and NO (NO) in the elderly patients with congestive heart failure. Methods 80 cases in our hospital from July 2015 to August 2016 were elderly patients with congestive heart failure as the research object,randomly divided into observation group ( n =40) and observation group two ( n =40),observation group using conventional treatment + tanshinone A treatment,observation group two group routine treatment,in addition to select health examination in the same period as a control group of 30 cases,using the New York Heart Association (NYHA) in patients with heart failure cardiac function grading standards,analysis index of heart function,BNP and NO levels of heart failure patients and healthy persons. Results NO and BNP levels were significantly decreased in two groups after treatment,LVEF increased significantly,and the observation group NO,a lower BNP level,higher level of LVEF ( P < 0.05);vWF was significantly decreased in two groups after treatment,6-keto-PGF1a increased significantly,and the observation group lower vWF level,higher level of 6-keto-PGF1a ( P < 0.05);patients with heart failure NO,BNP levels were significantly higher than the control group,the level of LVEF was significantly lower than the control group,heart function classification in patients with higher levels more obvious ( P < 0.05);the level of vWF in patients with heart failure was significantly higher than the control group,the level of 6-keto-PGF was significantly lower than the control group,heart function classification in patients with higher levels is more obvious ( P < 0.05);the observation group the total efficiency of two groups were 92.5 %,70 % and a group of observation,observation group rate was significantly higher ( P < 0.05). Conclusion VWF,6-keto-PGF1a and vascular endothelial function in patients with heart failure severity,treatment of elderly patients with congestive heart failure clinical use of tanshinone A,c

关 键 词：丹参酮ⅡA 充血性心衰 心功能 BNP NO 

分 类 号：R541.6[医药卫生—心血管疾病]