血清凝血酶原活动度及相关因素对重度慢性肝炎肝纤维化患者预后的影响分析  

An analysis of the effect of serum prothrombin activity (PTA) and related factors on prognosis of patients with severe chronic hepatitis with liver fibrosis

作　　者：王超秀[1] 陈炘[1] 刘发彬[1] 夏旭辉[1] WANG Chao-xiu;CHEN Xin;LIU Fa-bin;XIA Xu-hui(Department of Infectious Diseases,The First People's Hospital of Neijiang,Neijiang 641000,Sichuan,China)

机构地区：[1]内江市第一人民医院感染科

出　　处：《川北医学院学报》2019年第3期441-444,共4页Journal of North Sichuan Medical College

摘　　要：目的:分析重度慢性肝炎肝纤维化患者血清凝血酶原活动度(serum prothrombin activity,PTA)及其预后相关影响因素,为重度慢性肝炎肝纤维化患者个性化诊疗方案的制定提供参考依据。方法:收集122例重症肝炎合并肝纤维化患者的临床、影像学及流行病学资料,并对所有入选患者进行随访观察其预后状况。PTA检测采用SysmexCA-1500全自动血凝仪。结果:所有患者均获得完整随访,平均随访时间(27.14±11.73)个月;年龄、性别、身体质量指数(body mass index,BMI)、职业、医疗保险情况、吸烟量、酒精摄入量、是否有出血倾向、是否腹水、是否性功能减退、家族史、红细胞计量、白蛋白计量及血尿酸水平是影响患者PTA水平的因素;不同水平PTA患者的生存时间比较,差异有统计学意义(χ^2=16.627,P<0.001)。结论:重度慢性肝炎肝纤维化患者PTA可作为监测其预后状况的评估指标之一,高水平PTA患者的预后情况较好,低水平PTA患者的预后情况较差。Objective:To quantitatively analyze serum prothrombin activity (PTA) in patients with severe chronic hepatitis and fibrosis,and to analyze the prognostic factors,and to provide a personalized diagnosis and treatment plan for patients with severe chronic hepatitis and liver fibrosis.Methods:The clinical data,imaging data and epidemiological data were collected.All patients were followed up to observe the prognosis.Sysmex CA-1500 automatic blood coagulation instrument was used to detect PTA.Results:A total of 122 valid subjects were enrolled in the study.All patients were followed up for an average of 27.14±11.73 months.Age,gender,BMI,occupation,medical insurance,smoking,alcohol intake,bleeding tendency,ascites,sexual dysfunction,family history,red blood cell count,albumin measurement,and serum uric acid levels were factors influencing patients' PTA levels ( P <0.05).There was a statistically significant difference in survival time between patients with different levels of PTA (χ^2=16.627, P <0.001).Conclusion:PTA in patients with severe chronic hepatitis and liver fibrosis can be used as one of the evaluation indicators for monitoring the prognosis.The prognosis of patients with high-level PTA is better,and the prognosis of patients with low-level PTA is worse.

关 键 词：重度慢性肝炎 肝纤维化 血清凝血酶原活动度(PTA) 影响因素 预后 

分 类 号：R512.62[医药卫生—内科学] R575.2[医药卫生—临床医学]