阿托伐他汀联合普罗布考对颈动脉粥样硬化斑块及血浆ox-LDL的影响  

Effect of atorvastatin combined with probucol on carotid atherosclerotic plaque and plasma ox-LDL

作　　者：李海燕 肖韩艳[2] 张洲一 于雪 LI Haiyan;XIAO Hanyan;ZHANG Zhouyi;YU Xue(Department of Pharmacy,Hongqi Hospital Affiliated to Mudanjiang Medical Colledge,Mudanjiang 157000,China;Department of Neurology,Second Affiliated Hospital to Medanjiang Medical Colledge,Mudanjiang 157000,China;Center of Stroke, Hongqi Hospital Affiliated to Medanjiang Medical Colledge,Mudanjiang 157000,China)

机构地区：[1]牡丹江医学院附属红旗医院药学部,黑龙江牡丹江157000 [2]牡丹江医学院第二附属医院神经科,黑龙江牡丹江157000 [3]牡丹江医学院附属红旗医院卒中中心,黑龙江牡丹江157000

出　　处：《中国现代医生》2019年第16期1-3,共3页China Modern Doctor

基　　金：黑龙江省牡丹江市科学技术计划项目(Z2017s0044)

摘　　要：目的探讨阿托伐他汀联合普罗布考对颈动脉粥样硬化斑块及血浆ox-LDL的影响。方法回顾性分析我院2017年6月~2018年6月收治的100例颈动脉粥样硬化斑块患者的临床资料,通过随机抽签的方式分为两组,每组50例,对照组患者接受阿托伐他汀治疗,观察组接受阿托伐他汀联合普罗布考治疗,比较两种治疗方法对患者血浆ox-LDL、颈动脉内膜斑块面积变化的影响。结果治疗前,两组患者的ox-LDL水平、血脂水平、颈动脉内膜斑块面积检查结果比较,差异无显著性(P>0.05);治疗后,与对照组相比,观察组的ox-LDL水平较低,LDL-C、TC明显降低,颈动脉内膜斑块面积相对较小,差异有统计学意义(P<0.05),但HDL-C的水平变化不明显,差异无统计学意义(P>0.05)。结论在颈动脉粥样硬化斑块患者的治疗中,阿托伐他汀联合普罗布考治疗方法临床疗效明显,能够有效减少缺血性心脑血管病的发生。Objective To investigate the effects of atorvastatin combined with probucol on carotid atherosclerotic plaque and plasma ox-LDL. Methods The clinical data of 100 patients with carotid atherosclerotic plaque from June 2017 to June 2018 admitted to our hospital were retrospectively analyzed. And they were divided into two groups by random lottery, with 50 cases in each group. The control group was given atorvastatin treatment. The observation group was given atorvastatin combined with probucol. The effect of plasma ox-LDL and carotid endarterial plaque area were compared between the two treatment methods. Results Before treatment, there were no significant differences in ox-LDL levels, blood lipid levels, and carotid endometrial plaque area between the two groups(P>0.05). After treatment, compared with the control group, ox- LDL level of the observation group was lower, LDL-C and TC were significantly lowered, and the carotid intima plaque area was relatively small. The differences were statistically significant(P<0.05). The HDL-C level was not significantly changed, and the difference was not statistically significant(P<0.05). Conclusion In the treatment of patients with carotid atherosclerotic plaque, atorvastatin combined with probucol treatment has obvious clinical effects, which can effectively reduce the incidence of ischemic cardio-cerebral vascular disease.

关 键 词：颈动脉粥样硬化斑块 血浆 阿托伐他汀 普罗布考 

分 类 号：R543.5[医药卫生—心血管疾病]