类风湿关节炎外周Foxp3、TGF-β1与动脉粥样硬化的关系  

Relationship between Foxp3 and TGF-β1 and Atherosclerosis in Patients with Rheumatoid Arthritis

作　　者：牟晓月[1] 张幽幽[1] 陶海英[1] 金都[1] Mou Xiaoyue;Zhang Youyou;Tao Haiying(Department of Rheumatology and Immunology, Taizhou First People's Hospital, Zhejiang 318020, China)

机构地区：[1]台州市第一人民医院风湿免疫科

出　　处：《医学研究杂志》2019年第6期105-108,共4页Journal of Medical Research

基　　金：浙江省自然科学基金资助项目(LY16H120029)

摘　　要：目的探讨类风湿关节炎(rheumatoid arthritis,RA)患者外周血叉头转录因子3(forkhead transcription factor 3,Foxp3)、转化生子因子-β1(tsransforming growth factor-β1,TGF-β1)表达与动脉粥样硬化的相关性.方法选取2016年1月~2018年5月在笔者医院收治确诊为RA的患者126例作为RA组,将RA组分为RA有斑块组62例和RA无斑块组64例.同时选择笔者医院健康体检志愿者62例作为正常对照组,检测外周血Foxp3、TGF-β1表达水平和颈动脉内膜中层厚度(inteima-media thickness,IMT),采用回归分析筛选类风湿关节炎患者动脉粥样硬化的影响因素.结果 RA无斑块组和RA有斑块组研究对象的TC、TG和LDL高于正常对照组,HDL、TGF-β1水平和Foxp3 mRNA的相对表达量低于正常对照组,差异有统计学意义(P <0.05);RA有斑块组研究对象的TC、TG和LDL高于RA无斑块组,HDL、TGF-β1水平和Foxp3 mRNA的相对表达量低于RA无斑块组,差异有统计学意义(P<0.05).回归方程显示TC、LDL、Foxp3和TGF-β1为动脉粥样硬化的危险因素(P<0.05),HDL为动脉粥样硬化的保护因素(P<0.05).结论类风湿关节炎患者外周血中Foxp3、TGF-β1表达明显受到抑制,是动脉粥样硬化的危险因素,可能参与动脉粥样硬化的发生、发展.Objective To investigate the relationship between expression of fork head transcription factor 3 ( Foxp3 ), transforming growth factor-β1 ( TGF-β1) and atherosclerosis in patients with rheumatoid arthritis( RA). Methods 126 RA patients treated in our hospital from January 2016 to May 2018 were selected and set as RA group, which was further divided into two subgroups, namely RA plaque group( n = 62 ) and RA plaque - free group( n = 64). Another 62 health individuals were set as control group. Then the peripheral blood Foxp3 , TGF-β1 expression levels and carotid intima 一 media thickness( IMT) were detected. The influencing factors of inflammatory atherosclerosis were screened by regression analysis. Results The TC, TG, LDL, and IMT among three groups in a descending order was RA plaque group, RA plaque - free group and control group( P <0. 05). The expression of HDL, TGF -β1 and Foxp3 mRNA among three groups in an ascending order was RA plaque group, RA plaque - free group and control group( P < 0. 05 ). Regression analysis showed that TC, LDL, Foxp3 , and TGF -β1 were risk factors for atherosclerosis( P <0. 05), while HDL was a protective factor for atherosclerosis ( P < 0. 05 ). Conclusion The expression of Foxp3 and TGF -β1 in the peripheral blood of patients with rheumatoid arthritis is significantly inhibited. The two indicators are risk factor for atherosclerosis and may participate in the development of atherosclerosis.

关 键 词：类风湿关节炎 叉头转录因子3 转化生子因子-β1 动脉粥样硬化 

分 类 号：R593.22[医药卫生—内科学]