通过C-H键活化喹喔啉-2(1H)-酮催化功能化的研究进展（英文）  

Recent Advances on the Catalytic Functionalization of Quinoxalin-2(1H)-ones via C-H Bond Activation

作　　者：毛璞[1] 朱军亮 袁金伟[1] 杨亮茹[1] 肖咏梅[1] 张长森[2] Mao Pu;Zhu Junliang;Yuan Jinwei;Yang Liangru;Xiao Yongmei;Zhang Changsen(Academician Workstation for Natural Medicinal Chemistry of Henan Province,School of Chemistry & Chemical Engineering,Henan Univeristy of Technology,Zhengzhou 450001;College of Chemistry and Molecular Engineering,Zhengzhou University,Zhengzhou 450001)

机构地区：[1]河南工业大学化学化工学院河南省天然药物化学院士工作站,郑州450001 [2]郑州大学化学与分子工程学院,郑州450001

出　　处：《有机化学》2019年第6期1529-1547,共19页Chinese Journal of Organic Chemistry

基　　金：Project supported by the Department of Henan Province Natural Science and Technology Foundation(Nos.172102210225 and 182102310675);the Natural Science Foundation in Henan Province Department of Education(No.17A150005);the Program for Innovative Research Team from Zhengzhou(No.131PCXTD605);the Project of Youth Backbone Teachers of Henan University of Technology(No.2016003)~~

摘　　要：喹喔啉-2(1H)-酮是天然产物和药物中存在的一种非常重要的N-杂环化合物,具有广泛的生物活性.近年来,研究者对喹喔啉-2(1H)-酮的C-H键活化和功能化的进行了大量的研究,包括烷基化、苄基化、酰化、芳基化、胺化、酰胺化、膦酰化、氟烷基化等.综述了近年来该领域的研究进展,并对其反应机理进行了探讨.Quinoxalin-2(1H)-ones are very important N-heterocyclic moieties found in natural products and pharmaceuticals,and exhibit an amazingly wide spectrum of biological properties.Numerous efforts have been devoted to the development of efficient approaches for the C-H bond activation and functionalization of quinoxalin-2(1H)-ones in recent years,including alkylation,benzylation,acylation,arylation,amination,amidation,phosphonation,and fluoroalkylation.The recent advances in this area are summarized and their reaction mechanisms are discussed.

关 键 词：喹喔啉-2(1H)-酮 C-H键活化 功能化 过渡金属催化 

分 类 号：O621.251[理学—有机化学]