不对称氢甲酰化反应研究进展  

Recent Advances in Asymmetric Hydroformylation

作　　者：李帅龙 李庄星 由才 吕辉 张绪穆[3] Li Shuailong;Li Zhuangxing;You Cai;Lü Hui;Zhang Xumu(Key Laboratory of Biomedical Polymers of Ministry of Education,College of Chemistry and Molecular Sciences,Wuhan University,Wuhan 430072;Engineering Research Center of Organosilicon Compounds & Materials,Ministry of Education,College of Chemistry and Molecular Sciences,Wuhan University,Wuhan 430072;Department of Chemistry,Southern University of Science and Technology,Shenzhen Grubbs Institute,Shenzhen 518055;Sauvage Center for Molecular Sciences,Wuhan University,Wuhan 430072)

机构地区：[1]武汉大学化学与分子科学学院生物医用高分子材料教育部重点实验室,武汉430072 [2]武汉大学化学与分子科学学院有机硅化合物及材料教育部工程中心,武汉430072 [3]南方科技大学化学系深圳格拉布斯研究院,深圳518055 [4]武汉大学索维奇分子科学研究中心,武汉430072

出　　处：《有机化学》2019年第6期1568-1582,共15页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21871212);湖北省自然科学基金(No.2018CFB430)资助项目~~

摘　　要：烯烃的不对称氢甲酰化反应是合成手性醛的重要方法之一.近年来,不对称氢甲酰化反应研究取得了重要进展,发展了一系列适用于不对称氢甲酰化的新配体,实现了几类重要烯烃的不对称氢甲酰化反应,为手性醛的合成提供了简单高效的方法.介绍了不对称氢甲酰化研究的新进展,重点对几类代表性底物的不对称氢甲酰化反应以及相关配体进行了总结.Asymmetric hydroformylation is one of the most important reactions for preparation of chiral aldehydes from alkenes.Recently,significant progress has been made in this field and a series of new ligands have been developed.Asymmetric hydroformylation of several important alkenes has been achieved,offering efficient and concise methods for the synthesis of chiral aldehydes.In this review,the achievements of asymmetric hydroformylation of typical alkenes and the development of ligands for asymmetric hydroformylation are summarized.

关 键 词：烯烃 不对称氢甲酰化 醛 手性膦配体 铑 

分 类 号：O621.25[理学—有机化学] O641.4[理学—化学]