MIL-101（Cr）-SO3H催化2-取代喹啉衍生物转移氢化反应的研究  

MIL-101（Cr）-SO3H Catalyzed Transfer Hydrogenation of 2-Substituted Quinoline Derivatives

作　　者：陈晓玲[1] 陈静雯[1] 鲍宗必[1] 杨启炜[1] 杨亦文[1] 任其龙[1] 张治国[1] Chen Xiaoling;Chen Jingwen;Bao Zongbi;Yang Qiwei;Yang Yiwen;Ren Qilong;Zhang Zhiguo(Key Laboratory of Biomass Chemical Engineering of Ministry of Education,College of Chemical and Biological Engineering,Zhejiang University,Hangzhou 310027)

机构地区：[1]生物质化工教育部重点实验室浙江大学化学与生物工程学院

出　　处：《有机化学》2019年第6期1681-1687,共7页Chinese Journal of Organic Chemistry

基　　金：国家重点研发计划(No.2016YFA0202900);国家自然科学基金(Nos.21878266,21722609)资助项目~~

摘　　要：2-取代-1,2,3,4-四氢喹啉骨架广泛存在于天然产物中,具有抗疟、抗氧化等生物活性.报道了MIL-101(Cr)-SO3H催化以汉奇酯为氢供体的2-取代喹啉衍生物的转移氢化反应.该方法反应条件温和,适用于2位具有不同取代基的喹啉衍生物,催化剂易于回收和循环利用,为2-取代-1,2,3,4-四氢喹啉衍生物的合成提供了新途径.The 2-substituted-1,2,3,4-tetrahydroquinoline skeletons are widely found in natural products and have shown antimalarial,antioxidant as well as other biological activities.In this work,MIL-101(Cr)-SO3H is an efficient heterogeneous catalyst for the transfer hydrogenation of a series of 2-substituted quinoline derivatives with Hantzsch ester as the hydrogen source.This protocol operates under mild conditions,tolerates a wide range of 2-substituted quinoline derivatives,and the catalyst could be recovered and reused four times without considerable loss of catalytic activities,which provides a new catalytic system for the construction of 2-substituted-1,2,3,4-tetrahydroquinoline derivatives.

关 键 词：汉奇酯 多相催化 氢转移 MIL-101(Cr)-SO3H 1 2 3 4-四氢喹啉衍生物 

分 类 号：O621.251[理学—有机化学] O626.323[理学—化学]