抗苗勒管激素评估多囊卵巢综合症征、卵巢储备低下功能减退和卵巢早衰疾病的临床意义  

Clinical Significance of Anti-Mullerian Hormone in the Evaluation of Polycystic Ovary Syndrome,Hypofunction of Ovarian Reserve and Premature Ovarian Failure

作　　者：张艺[1] 欧阳振波[1] 谢元媚[1] 王亚玲[1] ZHANG Yi;OUYANG Zhenbo;XIE Yuanmei;WANG Yaling(Guangdong Second People's Hospital,Guangzhou 510317,China)

机构地区：[1]广东省第二人民医院

出　　处：《现代医院》2019年第6期918-920,共3页Modern Hospitals

摘　　要：目的探讨抗苗勒管激素(AMH)与多囊卵巢综合症征(PCOS)、卵巢储备低下功能减退(DOR)和卵巢早衰(POF)之间的关系。方法收集2017年6月-2018年6月在妇科就诊的患者作为研究对象,其中PCOS、DOR和POF患者各16例,收集14例女性健康志愿者作为对照组。收集所有研究对象的肘静脉血,测定其血清AMH、卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)和泌乳素(PRL)水平,比较其与PCOS、DOR和POF患者之间的关系。结果 PCOS组患者血清AMH、FSH、LH、LH/FSH、E2、PRL、T和FINS水平均高于对照组;DOR患者血清AMH、T和FINS水平显著低于对照组,而FSH、LH、LH/FSH、E2和PRL水平则显著高于对照组;POF组患者血清AMH、E2、PRL、T和FINS水平均显著低于对照组,而FSH、LH、LH/FSH水平则显著高于对照组。结论 PCOS患者血清AMH水平显著升高,而DOR和POF患者血清AMH水平则显著低于对照组,提示AMH水平可以作为早期诊断PCOS、DOR和POF疾病的指标之一,具有很大的临床意义。Objective To explore the relationship between anti-Mullerian hormone( AMH) and polycystic ovary syndrome( PCOS),ovarian reserve hypofunction( DOR) and premature ovarian failure( POF). Methods Patients who were admitted to the gynecology department from June 2017 to June 2018 were enrolled in the study. Among them,16 patients with PCOS,DOR and POF were enrolled,and 14 healthy volunteers were collected as a control group. Elbow venous blood was collected from all subjects,and serum AMH,follicle stimulating hormone( FSH),luteinizing hormone( LH),estradiol( E2),and prolactin( PRL) levels were measured and compared with patients with PCOS,DOR,and POF. Results The serum levels of AMH,FSH,LH,LH/FSH,E2,PRL,T and FINS in the PCOS group were higher than those in the control group;the serum AMH,T and FINS levels in DOR patients were significantly lower than those in the control group,while FSH,LH,LH/The levels of FSH,E2 and PRL were significantly higher than those of the control group. The levels of serum AMH,E2,PRL,T and FINS in the POF group were significantly lower than those in the control group,while the levels of FSH,LH and LH/FSH were significantly higher than those in the control group. Conclusion The serum AMH level of PCOS patients was significantly increased,while the serum AMH level of DOR and POF patients was significantly lower than that of the control group,suggesting that the AMH level can be used as one of the indicators for the early diagnosis of PCOS,DOR and POF diseases,which has great clinical significance.

关 键 词：抗苗勒管激素 多囊卵巢综合症征 卵巢储备低下功能减退 卵巢早衰 

分 类 号：R711.75[医药卫生—妇产科学]