Positron emission tomography/computed tomography imaging appearance of benign and classic “do not touch” osseous lesions  

作　　者：Stacey M Elangovan Ronnie Sebro 

机构地区：[1]Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, United States [2]Department of Orthopedic Surgery, University of Pennsylvania, Philadelphia, PA 19104, United States [3]Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, United States [4]Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA 19104, United States

出　　处：《World Journal of Radiology》2019年第6期81-93,共13页世界放射学杂志（英文版）（电子版）

摘　　要：BACKGROUND Classic “do not touch” and benign osseous lesions are sometimes detected on 18-Ffluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) studies. These lesions are often referred for biopsy because the physician interpreting the PET/CT may not be familiar with the spectrum of 18F-FDG uptake patterns that these lesions display. AIM To show that “do not touch” and benign osseous lesions can have increased 18FFDG uptake above blood-pool on PET/CT;therefore, the CT appearance of these lesions should dictate management rather than the standardized uptake values (SUV). METHODS This retrospective study evaluated 287 independent patients with 287 classic “do not touch”(benign cystic lesions, insufficiency fractures, bone islands, bone infarcts) or benign osseous lesions (hemangiomas, enchondromas, osteochondromas, fibrous dysplasia, Paget’s disease, osteomyelitis) who underwent 18F-FDG positron emission tomography/computed tomography (PET/CT) at a tertiary academic healthcare institution between 01/01/2006 and 12/1/2018. The maximum and mean SUV, and the ratio of the maximum SUV to mean blood pool were calculated. Pearson’s correlations between lesion size and maximum SUV were calculated. RESULTS The ranges of the maximum SUV were as follows: For hemangiomas (0.95-2.99), bone infarcts (0.37-3.44), bone islands (0.26-3.29), enchondromas (0.46-2.69), fibrous dysplasia (0.78-18.63), osteochondromas (1.11-2.56), Paget’s disease of bone (0.93-5.65), insufficiency fractures (1.06-12.97) and for osteomyelitis (2.57- 12.64). The range of the maximum SUV was lowest for osteochondromas (maximum SUV 2.56) and was highest for fibrous dysplasia (maximum SUV of 18.63). There was at least one lesion that demonstrated greater 18F-FDG avidity than the blood pool amongst each lesion type, with the highest maximum SUV ranging from 9.34 times blood pool mean (osteomyelitis) to 1.42 times blood pool mean (hemangiomas). There was no correlation between the maximum SUV and the lesion sBACKGROUND Classic "do not touch" and benign osseous lesions are sometimes detected on 18-F-fluorodeoxyglucose(18F-FDG) positron emission tomography/computed tomography（PET/CT） studies. These lesions are often referred for biopsy because the physician interpreting the PET/CT may not be familiar with the spectrum of 18F-FDG uptake patterns that these lesions display.AIM To show that "do not touch" and benign osseous lesions can have increased 18F-FDG uptake above blood-pool on PET/CT; therefore, the CT appearance of these lesions should dictate management rather than the standardized uptake values（SUV）.METHODS This retrospective study evaluated 287 independent patients with 287 classic "do not touch"（benign cystic lesions, insufficiency fractures, bone islands, bone infarcts） or benign osseous lesions（hemangiomas, enchondromas,osteochondromas, fibrous dysplasia, Paget’s disease, osteomyelitis） who underwent 18F-FDG positron emission tomography/computed tomography（PET/CT） at a tertiary academic healthcare institution between 01/01/2006 and 12/1/2018. The maximum and mean SUV, and the ratio of the maximum SUV to mean blood pool were calculated. Pearson’s correlations between lesion size and maximum SUV were calculated.RESULTS The ranges of the maximum SUV were as follows: For hemangiomas（0.95-2.99）,bone infarcts（0.37-3.44）, bone islands（0.26-3.29）, enchondromas（0.46-2.69）,fibrous dysplasia（0.78-18.63）, osteochondromas（1.11-2.56）, Paget’s disease of bone（0.93-5.65）, insufficiency fractures（1.06-12.97） and for osteomyelitis（2.57-12.64）. The range of the maximum SUV was lowest for osteochondromas（maximum SUV 2.56） and was highest for fibrous dysplasia（maximum SUV of 18.63）. There was at least one lesion that demonstrated greater 18F-FDG avidity than the blood pool amongst each lesion type, with the highest maximum SUV ranging from 9.34 times blood pool mean（osteomyelitis） to 1.42 times blood pool mean（hemangiomas）. There was no correlation be

关 键 词：Positron emission tomography/computed tomography Skeletal-axial Skeletal-appendicular “Do not touch” LESIONS 

分 类 号：R[医药卫生]