Inhibin B:are modified ranges needed for orchiectomised testicular cancer patients?  

作　　者：Alessandra Petrozzi Francesco Pallotti Marianna Pelloni Antonella Anzuini Antonio Francesco Radicioni Andrea Lenzi Donatella Paoli Francesco Lombardo 

机构地区：[1]Laboratory of Seminology, Sperm Bank "Loredana Gandini", Department of Experimental Medicine, Medical Pathophysiology Section,"Sapienza" University of Rome, Rome 00161, Italy [2]Hormone Laboratory, Department of Experimental Medicine, Medical Pathophysiology Section,"Sapienza" University of Rome, Rome 00161, Italy

出　　处：《Asian Journal of Andrology》2019年第4期332-336,共5页亚洲男性学杂志（英文版）

摘　　要：Inhibin B is a gon adal horm one that down regulates the pituitary production of follicle-stimulati ng horm one (FSH). In recent years, inhibin B has proved to be an excellent marker of spermatogenesis and even a predictive factor for the recovery of fertility in patients undergoing orchiectomy and antineoplastic treatments. We propose to study inhibin B levels in orchiectomised testicular cancer patients, in order to identify a minimum value representative of normal semen quality. This retrospective study evaluates horm onal and semen parameters of 290 no rmozoospermic patie nts atte nding the Laboratory of Semi no logy - Sperm Bank "Loredana Gandini"(Rome, Italy) for cryopreservation of seminal fluid following a diagnosis of testicular cancer (TC group) and 117 healthy, normozoospermic men as a control group (CTR group). The percentile distribution of gonadotropin and inhibin B values in the TC and CTR groups was analyzed. There was a statistically significant differenee between the two groups in the levels of all hormones (P ≤ 0.001) and in all semen parameters (P < 0.05). About 20% of TC patients revealed inhibin B levels below the 5th percentile of CTR group, despite normozoospermia, and 31.4% had normal spermatogenesis in the presenee of FSH values >95^th percentile of CTR group. Orchiectomised patients for testicular cancer presented inhibin B levels lower than healthy patients, despite normozoospermia. Our study revealed the poor sensitivity of the current inhibin B reference range when applied to monorchidic patients, suggesting the need to establish more representative ranges to enable more appropriate counseling in relation to the patienfs new endocrine condition.

关 键 词：INHIBIN B ORCHIECTOMY referenee RANGE TESTICULAR cancer 

分 类 号：R563[医药卫生—呼吸系统]