联合检测糖化血红蛋白、胱抑素C、血清淀粉样蛋白A、视黄醇结合蛋白对早期糖尿病肾病的诊断价值  

Diagnostic value of combined detection of HbA1c,CysC,SAA and RBP in early diabetic nephropathy

作　　者：李志伟[1] 李彩红[2] 郭辉[1] LI Zhiwei;LI Caihong;GUO Hui(Department of Clinical Laboratory, the First Hospital of Handan City t Handan 056001 , China;Department of Gynecology, Handan Maternity and Child Care Center, Handan 056001 , China)

机构地区：[1]邯郸市第一医院检验科,河北邯郸056001 [2]邯郸市妇幼保健院妇科,河北邯郸056001

出　　处：《现代医学》2019年第5期590-593,共4页Modern Medical Journal

摘　　要：目的:探讨联合检测糖化血红蛋白(Hb A1c)、胱抑素C(CysC)、血清淀粉样蛋白A(SAA)、视黄醇结合蛋白(RBP)在早期糖尿病肾病(DN)中的诊断价值。方法:选取64例早期DN患者(早期DN组)及60例单纯糖尿病患者(对照组),检测两组Hb A1c、CysC、SAA、RBP水平并进行比较。结果:早期DN组HbA1c、CysC、SAA、RBP水平分别为(8. 55±1. 63)%、(1. 68±0. 35) mg·L-1、(11. 28±2. 84) mg·L-1、(86. 45±9. 74) mg·L-1,均明显高于对照组(P <0. 05);早期DN组Hb A1c、CysC、SAA、RBP及4项联合的阳性检出率为78. 13%、70. 31%、62. 50%、67. 19%及96. 88%,均明显高于对照组(P <0. 05),且早期DN组4项指标联合检测阳性检出率明显高于各单项指标检出率(P <0. 05);早期DN组4项指标联合检测的诊断灵敏度、准确度为96. 88%、92. 74%,均明显高于各单项指标(P <0. 05)。结论:HbA1c、CysC、SAA、RBP与DN密切相关,联合检测对早期DN的诊断具有重要意义。Objective: To explore the diagnostic value of combined detection of glycosylated hemoglobin( HbA1 c),cystatin C( CysC),serum amyloid A( SAA) and retinol binding protein( RBP) in early diabetic nephropathy( DN). Methods: 64 patients with early-stage DN( early DN group) and 60 patients with diabetes( control group) were selected. The levels of HbA1 c,CysC,SAA,and RBP in the two groups were determined and compared. Results: The levels of Hb A1 c,CysC,SAA and RBP in early DN group were( 8. 55 ± 1. 63)%,( 1. 68 ± 0. 35) mg · L-1,( 11. 28 ± 2. 84) mg · L-1,( 86. 45 ± 9. 74) mg · L-1,respectively,which were significantly higher than those in the control group( P < 0. 05). The positive detection rates of Hb A1 c,CysC,SAA,RBP and the combination of four indicators in early DN group were 78. 13%,70. 31%,62. 50%,67. 19%,96. 88%,which were significantly higher than those in the control group( P < 0. 05),and the positive detection rate of the combination of four indicators was significantly higher than that of the individual indicator in early DN group( P < 0. 05). The sensitivity and accuracy of the joint detection of the four indicators in early DN group were96. 88% and 92. 74% respectively,which were significantly higher than those of the individual indicator( P <0. 05). Conclusion: HbA1 c,CysC,SAA,RBP are closely related to diabetic nephropathy,and joint detection is of great significance in the diagnosis of early renal damage.

关 键 词：糖尿病肾病 糖化血红蛋白 胱抑素C 血清淀粉样蛋白 视黄醇结合蛋白 

分 类 号：R587.2[医药卫生—内分泌]