固体脂质纳米粒的研究进展  

Research Progress of Solid Lipid Nanoparticles

作　　者：郭童林 王翠 沈丽霞 GUO Tong-lin;WANG Cui;SHEN Li-xia(Department of Pharmacy,Hebei North University,Hebei Key Laboratory of Neuropharmacology,Zhangjiakou,075000,China)

机构地区：[1]河北北方学院药学系,河北省神经药理学重点实验室,张家口075000

出　　处：《神经药理学报》2017年第6期15-21,共7页Acta Neuropharmacologica

基　　金：河北省自然科学基金资助项目(No.H2012405016);河北省高等学校科学技术研究项目(No.ZD2015131).

摘　　要：固体脂质纳米粒(solid lipid nanoparticles,SLN)是由天然存在或人工合成的固态类脂为载体,将药物镶嵌于类脂核或和黏附于类脂表面制备而成的固体胶粒给药系统,粒径在10~1 000 nm 之间。固体脂质纳米粒所用的载体均为无毒或低毒性、生物相容性好、生物可降解的类脂,是20 世纪90 年代初发展起来的新一代亚微粒给药系统。固体脂质纳米粒具有控制药物释放、避免药物的降解或泄漏以及良好的靶向性等优点。该文对固体脂质纳米粒基本组成成分、制备方法、影响载药量(drug loading,DL)和包封率(entrapment efficiency,EE)的因素、载药系统的释放以及固体脂质纳米粒的应用、优势等方面进行综述。Solid lipid nanoparticles (SLN) is a solid colloidal drug delivery system based on natural or synthetic solid lipids embedded in lipophilic nuclei or coated on lipopolipid surfaces. The particle size of SLN is 10~1 000 nm. The carriers used in solid lipid nanoparticles are lipid-like compounds with low toxicity,good biocompatibility and biodegradability. It is a new generation of submicron drug delivery system developed in the early 1990s. Solid lipid nanoparticles have the advantages of controlling drug release,avoiding drug degradation or leakage,and good targeting. This paper summarized and analyzed the research progress of solid lipid nanoparticles,including the basic components,preparation methods,factors affecting drug loading (DL) and encapsulation efficiency (EE),drug delivery system release,the application and advantages of solid lipid nanoparticles.

关 键 词：固体脂质纳米粒 载体 靶向性 

分 类 号：R944[医药卫生—药剂学]