脑缺血再灌注损伤及其星形胶质细胞相关机制研究进展  

Research Progress of Cerebral Ischemia Reperfusion Injury and Its Mechanisms Related to Astrocytes

作　　者：李江曼 王一頔 王风萍 李炜 LI Jiang-man;WANG Yi-di;WANG Feng-ping;LI Wei(Department of Pharmacy,Hebei North University,Hebei Key Laboratory of Neuropharmacology,Zhangjiakou, 075000,China)

机构地区：[1]河北北方学院药学系,河北省神经药理学重点实验室,张家口075000

出　　处：《神经药理学报》2017年第6期50-59,共10页Acta Neuropharmacologica

基　　金：河北省自然科学基金资助项目(No.H2016208058);河北省教育厅项目(No.2010212);河北省卫生计生委医学科学研究重点课题(No.20170178);河北北方学院面上项目(No.12995363).

摘　　要：脑缺血再灌注损伤的机制尚未完全阐明,炎症反应、氧化应激、兴奋性氨基酸毒性、细胞内钙超载、能量代谢障碍和细胞凋亡等多方面机制互相影响、错综复杂。星形胶质细胞广泛分布于神经元之间,起支持、分隔、调控等作用,对神经系统具有重要功能,如吸收突触外的谷氨酸,调节K+体内平衡,缓冲活性氧过多产生等。该文通过综述近年来脑缺血再灌注损伤中有关星形胶质细胞的机制研究,为以星形胶质细胞为调控靶点改善脑缺血再灌注损伤的研究提供依据和新思路。The mechanism of cerebral ischemia-reperfusion injury has not been fully elucidated,and various mechanisms are mutually influential and complicated,such as inflammatory response,oxidative stress,excitatory amino acid toxicity,intracellular calcium overload,energy metabolism disorder and apoptosis and so on. Astrocytes widely distributed between neurons,can support,separate,and regulate neurons. And they have important functions on the nervous system,such as absorbing glutamate outside the synapse,regulating K+ homeostasis,and buffering excessive production of reactive oxygen species. In this paper,we review the mechanism of astrocytes in cerebral ischemia-reperfusion injury in recent years,and provide a basis and new ideas for the study of astrocytes as a target to improve cerebral ischemiareperfusion injury.

关 键 词：脑缺血再灌注损伤 星形胶质细胞 神经保护 能量代谢障碍 小分子核糖核酸 

分 类 号：R964[医药卫生—药理学]