脓毒性脑病的神经化学机制研究进展  

The Progress of Neurochemical Mechanisms in Septic Encephalopathy

作　　者：金晔[1] 赵博伦 韩晓菲[1] 刘庆平[1] 王欢[1] JIN Ye;ZHAO Bo-lun;HAN Xiao-fei;LIU Qing-ping;WANG Huan(Key Laboratory of Glycolipid Metabolism of Liaoning Province,College of Life Science and Technology,Dalian University,Dalian 116622,Liaoning,China;School of Nursing,Dalian University,Dalian 106011,Liaoning,Chian)

机构地区：[1]大连大学生命科学与技术学院辽宁省糖脂代谢重点实验室,中国辽宁大连116622 [2]大连大学护理学院,中国辽宁大连106011

出　　处：《生命科学研究》2019年第3期219-225,共7页Life Science Research

基　　金：国家自然科学基金资助项目(81673417,81302748);辽宁省科技厅博士启动基金指导计划项目(20161297)

摘　　要：脓毒性脑病是一种脓毒症所引起的全身性炎症反应,在多器官功能障碍综合征患者中出现。脓毒性脑病与多种炎症因子及化学物质有关。这些炎症因子可在全身引起炎症反应,破坏血脑屏障并影响脑功能,引起突触传递及可塑性异常等神经系统相关的病症。文中对近年来脓毒性脑病发病过程中所涉及的神经递质失衡、突触传递异常及相关神经调节作用以及检测神经递质的量子点技术进行综述总结,旨在推进未来脓毒性脑病的研究。Septic encephalopathy is brain dysfunction mediated by the septic inflammatory response.It appears in patients with multiple organ dysfunction syndrome(MODS).Septic encephalopathy is associated with many kinds of inflammatory cytokines and chemicals.These inflammatory molecules induce systemic inflammatory response,trigger blood-brain barrier disruption and affect the brain function,leading to neurological symptoms such as aberrant synaptic transmission and plasticity.Herein,the imbalance of neurotransmitter,impairment of synaptic transmission,effect of nervous regulation and application of quantum dots in septic encephalopathy are summarized,aiming at facilitating its future research.

关 键 词：脓毒性脑病 神经递质 胆碱能抗炎通路 量子点 

分 类 号：Q291[生物学—细胞生物学] R189[医药卫生—流行病学]